Shubina Larisa K, Makarieva Tatyana N, Denisenko Vladmir A, Dmitrenok Pavel S, Dyshlovoy Sergey A, von Amsbert Gunhild, Glazunov Valery P, Silchenko Artem S, Stonik Inna V, Lee Hyi-Seung, Lee Yeon-Ju, Stonik Valentin A
Nat Prod Commun. 2016 Sep;11(9):1253-1257.
As a result of the first study on secondary metabolites from the cosmopolitan bioluminescent marine tube polychaete Chaetopterus variopedatus, a new bicyclic guanidine alkaloid, 6-epi-monanchorin (1), along with the previously known monanchorin (2) were isolated. The structure of 1 was elucidated by spectroscopic and chemical methods, including a cleavage of the C₁-0₇ bond to obtain a secondary alcohol (3), which was used to determine the absolute configurations by Mosher's method. It was found that 1 and 2 were mainly accumulated in a secreted mucus special organ of the worm (food net), where green and blue-green microalgae were detected. A biosynthetic pathway to 6-epi-monanchorin and monanchorin from dietary polyeic fatty acid precursors was proposed.
作为对全球分布的发光海洋管栖多毛类动物多毛纲缨鳃虫次生代谢产物的首次研究成果，一种新的双环胍生物碱6-表单锚菌素（1）与先前已知的单锚菌素（2）被分离出来。通过光谱和化学方法阐明了1的结构，包括断裂C₁-O₇键以获得仲醇（3），该仲醇用于通过莫舍尔方法确定绝对构型。研究发现，1和2主要积累在蠕虫的一个分泌黏液的特殊器官（食物网）中，在该器官中检测到了绿色和蓝绿色微藻。提出了从膳食多烯脂肪酸前体合成6-表单锚菌素和单锚菌素的生物合成途径。
