Wu Huaiyu, Liang Weiyu, Jiao Yang, Song Hong, Peng Quanzhou, Luo Hui, Zhang Yuanji, Xu Jinfeng, Dong Fajin
Department of Ultrasound, Shenzhen Medical Ultrasound Engineering Center, and.
Department of Pathology, Shenzhen People's Hospital, the Second Clinical Medical College of Jinan University, Shenzhen, China.
Ultrasound Q. 2019 Mar;35(1):88-92. doi: 10.1097/RUQ.0000000000000434.
The purpose of this study was to compare the diagnostic value of Young's modulus (E) and shear modulus (G) in the differential diagnosis of benign and malignant breast masses using sound touch elastography (STE) and to explore the relationship between G and E in breast lesions.
A total of 96 consecutive women with 110 pathologically confirmed breast masses were included. All masses were detected by conventional and STE ultrasound. Emean, Emax, Emin, ESD, Gmean, Gmax, Gmin, and GSD were determined and evaluated for evidence of significant differences between benign and malignant breast masses. Receiver operator characteristics were used to compare the diagnostic efficacy of E and G and to determine the G cutoff value that would aid in the differential diagnosis of breast cancer.
Emean, Emax, ESD, Gmean, Gmax, and GSD in cases of malignant breast masses were significantly higher than those in cases of benign masses (P < 0.05). There was no significant difference between Emin and Gmin (P = 0.565). In applying the Emean, Emax, ESD, Gmean, Gmax, and GSD to the receiver operator characteristics: (1) the area under the curve (AUC) of Gmean and Gmax is greater than the AUC of Emean and Emax, and the AUC of ESD is equal to the AUC of GSD. (2) The sensitivity and specificity were highest when the Gmean was 10.14 kPa. They were 84.1% and 80.3% respectively. (3) The sensitivity and specificity were highest when the Gmax was 52.20 kPa. They were 88.6% and 87.9% respectively.
These preliminary results of STE evaluation of breast masses suggest that the diagnostic value of G is greater than E. Furthermore, STE is a valuable tool in the differential diagnosis of breast lesions.
本研究旨在比较杨氏模量（E）和剪切模量（G）在利用声触诊弹性成像（STE）鉴别乳腺良恶性肿块中的诊断价值，并探讨乳腺病变中G与E之间的关系。
纳入96例连续的女性患者，共110个经病理证实的乳腺肿块。所有肿块均通过常规超声和STE超声进行检测。测定Emean、Emax、Emin、ESD、Gmean、Gmax、Gmin和GSD，并评估乳腺良恶性肿块之间是否存在显著差异。采用受试者工作特征曲线比较E和G的诊断效能，并确定有助于乳腺癌鉴别诊断的G临界值。
乳腺恶性肿块病例中的Emean、Emax、ESD、Gmean、Gmax和GSD显著高于良性肿块病例（P<0.05）。Emin和Gmin之间无显著差异（P=0.565）。将Emean、Emax、ESD、Gmean、Gmax和GSD应用于受试者工作特征曲线时：（1）Gmean和Gmax的曲线下面积（AUC）大于Emean和Emax的AUC，ESD的AUC等于GSD的AUC。（2）当Gmean为10.14 kPa时，敏感性和特异性最高，分别为84.1%和80.3%；（3）当Gmax为52.20 kPa时，敏感性和特异性最高，分别为88.６%和87.9%。
STE评估乳腺肿块的这些初步结果表明，G的诊断价值大于E。此外，STE是乳腺病变鉴别诊断中的一种有价值的工具。
