Scherkl R, Frey H H
Pharmacology. 1986;32(1):18-24. doi: 10.1159/000138148.
Six dogs were, under constant environmental conditions, treated for 7 weeks with clonazepam (0.5 mg/kg b.i.d. orally). Already after 1 week of treatment, slight symptoms of withdrawal could be elicited by intravenous injection of flumazepil (Ro 15-1788). When clonazepam was finally withdrawn, a self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss. The syndrome was most pronounced on days 2 and 3 after withdrawal, after 1 week all signs of physical dependence had disappeared.
六只狗在恒定的环境条件下，口服氯硝西泮（0.5毫克/千克，每日两次）治疗7周。治疗1周后，静脉注射氟马西尼（Ro 15 - 1788）即可引发轻微的戒断症状。当最终停用氯硝西泮时，所有狗均出现了一种自限性戒断综合征，包括行为改变（无精打采、像湿狗一样抖动、仰卧）、震颤、1例出现严重的阵挛 - 强直发作、体温过高和体重减轻。该综合征在停药后的第2天和第3天最为明显，1周后所有身体依赖的迹象均消失。
