Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA.
Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA.
DNA Repair (Amst). 2019 Apr;76:20-29. doi: 10.1016/j.dnarep.2019.02.002. Epub 2019 Feb 8.
Poly(ADP-ribosyl)ation (PARylation) is a reversible post-translational modification regulating various biological pathways including DNA damage repair (DDR). Rapid turnover of PARylation is critically important for an optimal DNA damage response and maintaining genomic stability. Recent studies show that PARylation is tightly regulated by a group of enzymes that can erase the ADP-ribose (ADPR) groups from target proteins. The aim of this review is to present a comprehensive understanding of dePARylation enzymes, their substrates and roles in DDR. Special attention will be laid on the role of these proteins in the development of cancer and their feasibility in anticancer therapeutics.
聚（ADP-核糖）化（PARylation）是一种可逆的翻译后修饰，调节包括 DNA 损伤修复（DDR）在内的多种生物途径。PARylation 的快速转换对于最佳的 DNA 损伤反应和维持基因组稳定性至关重要。最近的研究表明，PARylation 受到一组可以从靶蛋白上去除 ADP-核糖（ADPR）基团的酶的严格调控。本综述旨在全面了解去 PARylation 酶、其底物以及它们在 DDR 中的作用。特别关注这些蛋白质在癌症发展中的作用及其在抗癌治疗中的可行性。
