Kauppila A, Heikkinen J, Viinikka L
Acta Endocrinol (Copenh). 1986 Jan;111(1):10-6. doi: 10.1530/acta.0.1110010.
We evaluated the clinical applicability of a 2-h test in which the prolactin (Prl) responses to thyrotrophin releasing hormone (TRH)(200 micrograms iv) and the dopamine antagonist, metoclopramide (MC; 10 mg iv) were studied successively, 1 h apart. Nine healthy women were studied with TRH-MC test and with another test in which MC alone was used or the drugs were given in opposite order. The preceding TRH injection did not affect the Prl responses to MC, nor did preceding MC affect the Prl response to TRH. With the TRH-MC test, Prl responses to TRH and MC were significantly lowered in amenorrhoea (N = 8) and hyperprolactinaemia (N = 15) regardless of whether or not treated with bromocriptine, and to MC only in oligomenorrhoea (n = 11). In normoprolactinaemic galactorrhoea (N = 7) the responses were similar as in healthy women. The ratio between Prl responses to TRH and MC was significantly higher in women with bromocriptine-treated hyperprolactinaemia (1.06 +/- 0.8, SD) than in healthy controls (0.34 +/- 0.13). The capacity of pituitary lactotrophs to secrete Prl in response TRH and MC can be evaluated with a 2-h test which has potential for investigation of pituitary Prl dynamics in gynaecological endocrine disorders, particularly in amenorrhoea and hyperprolactinaemia.
我们评估了一项2小时测试的临床适用性，该测试依次研究了催乳素（Prl）对促甲状腺激素释放激素（TRH，静脉注射200微克）和多巴胺拮抗剂甲氧氯普胺（MC，静脉注射10毫克）的反应，两次注射间隔1小时。对9名健康女性进行了TRH-MC测试，以及另一种单独使用MC或药物注射顺序相反的测试。先前注射的TRH不影响Prl对MC的反应，先前注射的MC也不影响Prl对TRH的反应。通过TRH-MC测试，无论是否接受溴隐亭治疗，闭经患者（N = 8）和高催乳素血症患者（N = 15）中Prl对TRH和MC的反应均显著降低，而在月经过少患者（n = 11）中仅对MC的反应降低。在正常催乳素血症伴溢乳的患者（N = 7）中，反应与健康女性相似。接受溴隐亭治疗的高催乳素血症女性中Prl对TRH和MC的反应比值（1.06±0.8，标准差）显著高于健康对照组（0.34±0.13）。垂体催乳细胞对TRH和MC反应分泌Prl的能力可通过一项2小时测试进行评估，该测试在研究妇科内分泌疾病，特别是闭经和高催乳素血症的垂体Prl动态方面具有潜力。
