Halliday A M
Adv Neurol. 1986;43:339-55.
Early observations, made between 1935 and 1947, on the EEG discharges associated with myoclonic jerking are reviewed, together with the contemporary findings on the stimulus-sensitive myoclonus produced in cats under chloralose anesthesia. The accumulating evidence on the relative roles of cortex, brainstem, and cerebellum in producing this type of myoclonus is briefly summarized. The significance of large SEPs and their presence and absence in various clinical types of myoclonus is considered. Three distinctions are drawn with regard to the clinical features of myoclonic jerking: between action myoclonus and myoclonus at rest; between focal and generalized jerking; and between the lightning-like, irregular, stimulus-sensitive jerks of myoclonic epilepsy and the rhythmical, stimulus-insensitive jerking of segmental myoclonus. Some findings bearing on the possible mechanisms of the abnormal discharges responsible at cell membrane level are mentioned.
回顾了1935年至1947年间对与肌阵挛性抽搐相关的脑电图放电的早期观察，以及同时期关于在水合氯醛麻醉下猫产生的刺激敏感性肌阵挛的研究结果。简要总结了关于皮质、脑干和小脑在产生这种类型肌阵挛中相对作用的越来越多的证据。考虑了大体感诱发电位的意义及其在各种临床类型肌阵挛中的出现与缺失情况。就肌阵挛性抽搐的临床特征进行了三点区分：动作性肌阵挛与静止性肌阵挛之间；局灶性抽搐与全身性抽搐之间；肌阵挛性癫痫的闪电样、不规则、刺激敏感性抽搐与节段性肌阵挛的节律性、刺激不敏感性抽搐之间。还提到了一些与细胞膜水平异常放电可能机制相关的发现。
