MYBL2对中国胃腺癌切除患者的预后影响
Prognostic implications of MYBL2 in resected Chinese gastric adenocarcinoma patients.
作者信息
Jia Yongxu, Gao Yaping, Li Jing, Chang Zhiwei, Yan Jie, Qin Yanru
机构信息
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, People's Republic of China,
出版信息
Onco Targets Ther. 2019 Feb 11;12:1129-1135. doi: 10.2147/OTT.S188820. eCollection 2019.
BACKGROUND AND AIM
Gastric cancer (GC), a malignant tumor worldwide, is mostly diagnosed at an advanced stage. We selected the oncogene encoding transcription factors MYBL2 to investigate the connection between MYBL2 expression and GC prognosis.
MATERIALS AND METHODS
MYBL2 mRNA and protein expression were measured by real-time PCR and immunohistochemistry, respectively. The relationship between MYBL2 protein expression and survival time was estimated by the Kaplan-Meier analysis. Cox proportional hazards model was used to evaluate the prognostic impact of MYBL2 expression.
RESULTS
The overexpression of MYBL2 was related to tumor cell differentiation, Lauren type, and metastasis of lymph nodes (<0.05). In the MYBL2 overexpression group, the median disease free survival was even poorer (=0.000) and it comes to median overall survival (=0.000). The study showed that MYBL2 expression was an independent hazard for disease free survival (=0.004).
CONCLUSION
The results of this study suggest that MYBL2 could indicate a promisingly prognostic biomarker for GC patients.
背景与目的
胃癌（GC）是一种全球范围内的恶性肿瘤，大多在晚期被诊断出来。我们选择了编码转录因子MYBL2的致癌基因，以研究MYBL2表达与GC预后之间的联系。
材料与方法
分别通过实时聚合酶链反应和免疫组织化学检测MYBL2信使核糖核酸和蛋白质的表达。采用Kaplan-Meier分析评估MYBL2蛋白表达与生存时间之间的关系。使用Cox比例风险模型评估MYBL2表达对预后的影响。
结果
MYBL2的过表达与肿瘤细胞分化、劳伦分型及淋巴结转移相关（<0.05）。在MYBL2过表达组中，无病生存期的中位数更差（=0.000），总生存期的中位数也是如此（=0.000）。研究表明，MYBL2表达是无病生存期的独立危险因素（=0.004）。
结论
本研究结果表明，MYBL2可能是GC患者有前景的预后生物标志物。
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