诱导B记忆细胞的抗原需求：与偶联于T细胞依赖性和T细胞非依赖性载体的二硝基苯基的研究
Antigen requirements for induction of B-memory cells: studies with dinitrophenyl coupled to T-dependent and T-independent carriers.
作者信息
Braley-Mullen H
出版信息
J Exp Med. 1978 Jun 1;147(6):1824-31. doi: 10.1084/jem.147.6.1824.
Abstract
Mice were primed with dinitrophenyl (DNP) (trinitrophenyl, TNP) coupled to thymus-independent (TI) or thymus-dependent (TD) carriers. B cells from these mice were transferred to irradiated recipients with T cells from keyhole limpet hemocyanin (KLH)-primed mice. After secondary immunization with DNP-KLH a significant DNP-specific IgG memory response was produced only by mice which received B cells which had been primed with TD antigens. TI antigens were unable to induce differentiation of B-cell precursors to IgG producing memory B cells but they did not suppress the induction of B-memory cells by TD antigens. The results indicate that TI antigens fail to activate a cell type which is required for the induction of memory B cells.
摘要
用与非胸腺依赖性（TI）或胸腺依赖性（TD）载体偶联的二硝基苯基（DNP）（三硝基苯基，TNP）对小鼠进行致敏。将这些小鼠的B细胞与来自钥孔戚血蓝蛋白（KLH）致敏小鼠的T细胞一起转移到经辐照的受体中。在用DNP-KLH进行二次免疫后，仅接受过TD抗原致敏的B细胞的小鼠产生了显著的DNP特异性IgG记忆反应。TI抗原无法诱导B细胞前体分化为产生IgG的记忆B细胞，但它们并未抑制TD抗原诱导B记忆细胞的产生。结果表明，TI抗原未能激活诱导记忆B细胞所需的细胞类型。
相似文献
1
Antigen requirements for induction of B-memory cells: studies with dinitrophenyl coupled to T-dependent and T-independent carriers.诱导B记忆细胞的抗原需求：与偶联于T细胞依赖性和T细胞非依赖性载体的二硝基苯基的研究
J Exp Med. 1978 Jun 1;147(6):1824-31. doi: 10.1084/jem.147.6.1824.
2
3
Generation of immune memory by haptenated derivatives of thymus-independent antigens in C57BL/6 mice. I. The differentiation of memory B lymphocytes into antibody-secreting cells depends on the nature of the thymus-independent carrier used for memory induction and/or revelation.C57BL/6小鼠中胸腺非依赖性抗原的半抗原化衍生物诱导免疫记忆。I. 记忆B淋巴细胞分化为抗体分泌细胞取决于用于记忆诱导和/或揭示的胸腺非依赖性载体的性质。
Cell Immunol. 1983 Jan;75(1):52-62. doi: 10.1016/0008-8749(83)90304-0.
4
Reaginic antibody formation in the mouse. V. Adoptive antihapten IgE antibody response of dinitrophenyl-keyhole limpet hemocyanin-primed spleen cells cultured with dinitrophenyl heterologous carrier conjugates.小鼠体内反应素性抗体的形成。V. 用二硝基苯基-异源载体偶联物培养经二硝基苯基-钥孔戚血蓝蛋白致敏的脾细胞的过继抗半抗原IgE抗体反应
J Immunol. 1975 Feb;114(2 Pt 1):615-20.
5
Epitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responses.表位特异性调节。I. 针对IgG抗半抗原抗体应答的载体特异性抑制诱导。
J Exp Med. 1982 Jun 1;155(6):1730-40. doi: 10.1084/jem.155.6.1730.
6
Immunopotentiation by SGP and Quil A. II. Identification of responding cell populations.SGP和Quil A的免疫增强作用。II. 应答细胞群体的鉴定。
Cell Immunol. 1986 Apr 15;99(1):128-39. doi: 10.1016/0008-8749(86)90222-4.
7
T cell dependent and independent steps in IgE-B memory cell development.IgE-B记忆细胞发育中T细胞依赖和非依赖步骤。
Int Arch Allergy Appl Immunol. 1980;63(3):284-93. doi: 10.1159/000232638.
8
B cell memory to thymus-independent antigens type 1 and type 2: the role of lipopolysaccharide in B memory induction.B细胞对1型和2型非胸腺依赖性抗原的记忆：脂多糖在B细胞记忆诱导中的作用。
Eur J Immunol. 1988 Sep;18(9):1417-24. doi: 10.1002/eji.1830180918.
9
Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory.B细胞记忆的研究。II. 非T细胞依赖性抗原可诱导B细胞记忆。
Immunology. 1979 Oct;38(2):291-9.
10
Selective roles of thymus-derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specific IgM and IgG antibody responses.胸腺来源淋巴细胞在抗体应答中的选择性作用。I. 载体致敏T细胞对半抗原特异性IgM和IgG抗体应答的差异抑制作用。
J Exp Med. 1974 Jul 1;140(1):239-52. doi: 10.1084/jem.140.1.239.
引用本文的文献
1
Innate B cell helpers reveal novel types of antibody responses.先天 B 细胞辅助细胞揭示了新型的抗体应答类型。
Nat Immunol. 2013 Feb;14(2):119-26. doi: 10.1038/ni.2511. Epub 2013 Jan 18.
2
Immunological features of psoriasis. Effects of Ro-109359, concanavalin A, pokeweed mitogen, and methotrexate on cultivated lymphocytes.银屑病的免疫学特征。Ro-109359、伴刀豆球蛋白A、商陆有丝分裂原和甲氨蝶呤对培养淋巴细胞的影响。
Arch Dermatol Res. 1981;271(1):29-40. doi: 10.1007/BF00417385.
3
4
Cyclic development of immunological memory to bacterial lipopolysaccharide.对细菌脂多糖免疫记忆的周期性发展。
Infect Immun. 1985 Apr;48(1):1-6. doi: 10.1128/iai.48.1.1-6.1985.
5
Regulation of IgG memory responses by helper and suppressor T cells activated by the type 2 antigen, polyvinylpyrrolidone.由2型抗原聚乙烯吡咯烷酮激活的辅助性T细胞和抑制性T细胞对IgG记忆反应的调节
J Exp Med. 1985 Jun 1;161(6):1357-67. doi: 10.1084/jem.161.6.1357.
6
Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory.B细胞记忆的研究。II. 非T细胞依赖性抗原可诱导B细胞记忆。
Immunology. 1979 Oct;38(2):291-9.
本文引用的文献
1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
3
Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide.小鼠体内针对聚乙烯吡咯烷酮和大肠杆菌脂多糖的非胸腺依赖性体液抗体产生的证据。
Cell Immunol. 1971 Oct;2(5):411-24. doi: 10.1016/0008-8749(71)90052-9.
4
5
Thymus cell population exerting a regulatory function in the immune response of mice to polyvinyl pyrrolidone.在小鼠对聚乙烯吡咯烷酮的免疫反应中发挥调节功能的胸腺细胞群体。
Cell Immunol. 1974 Jul;13(1):76-86. doi: 10.1016/0008-8749(74)90228-7.
6
Evidence for readily induced tolerance to heterologous erythrocytes in nude mice.裸鼠对异种红细胞易诱导耐受性的证据。
Scand J Immunol. 1974;3(1):39-49. doi: 10.1111/j.1365-3083.1974.tb01231.x.
7
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
8
Effects of antilymphocyte serum on thymic independent immunity. 1. Lack of immunosuppressive action on the antibody response to E. coli lipopolysaccharide.抗淋巴细胞血清对胸腺非依赖免疫的作用。1. 对大肠杆菌脂多糖抗体反应缺乏免疫抑制作用。
Cell Immunol. 1973 Jun;7(3):380-8. doi: 10.1016/0008-8749(73)90202-5.
9
Immunological B memory in thymus deprived mice.胸腺缺失小鼠的免疫B记忆
Nat New Biol. 1972 Sep 13;239(89):63-4. doi: 10.1038/newbio239063a0.
10
Strain differences in the antibody plaque-forming cell responses of inbred mice to pneumococcal polysaccharide.近交系小鼠对肺炎球菌多糖的抗体空斑形成细胞反应中的品系差异。
Cell Immunol. 1971 Feb;2(1):73-81. doi: 10.1016/0008-8749(71)90026-8.
Zotero 插件