诱导B记忆细胞的抗原需求：与偶联于T细胞依赖性和T细胞非依赖性载体的二硝基苯基的研究
Antigen requirements for induction of B-memory cells: studies with dinitrophenyl coupled to T-dependent and T-independent carriers.
作者信息
Braley-Mullen H
出版信息
J Exp Med. 1978 Jun 1;147(6):1824-31. doi: 10.1084/jem.147.6.1824.
Abstract
Mice were primed with dinitrophenyl (DNP) (trinitrophenyl, TNP) coupled to thymus-independent (TI) or thymus-dependent (TD) carriers. B cells from these mice were transferred to irradiated recipients with T cells from keyhole limpet hemocyanin (KLH)-primed mice. After secondary immunization with DNP-KLH a significant DNP-specific IgG memory response was produced only by mice which received B cells which had been primed with TD antigens. TI antigens were unable to induce differentiation of B-cell precursors to IgG producing memory B cells but they did not suppress the induction of B-memory cells by TD antigens. The results indicate that TI antigens fail to activate a cell type which is required for the induction of memory B cells.
摘要
用与非胸腺依赖性（TI）或胸腺依赖性（TD）载体偶联的二硝基苯基（DNP）（三硝基苯基，TNP）对小鼠进行致敏。将这些小鼠的B细胞与来自钥孔戚血蓝蛋白（KLH）致敏小鼠的T细胞一起转移到经辐照的受体中。在用DNP-KLH进行二次免疫后，仅接受过TD抗原致敏的B细胞的小鼠产生了显著的DNP特异性IgG记忆反应。TI抗原无法诱导B细胞前体分化为产生IgG的记忆B细胞，但它们并未抑制TD抗原诱导B记忆细胞的产生。结果表明，TI抗原未能激活诱导记忆B细胞所需的细胞类型。
相似文献
1
Antigen requirements for induction of B-memory cells: studies with dinitrophenyl coupled to T-dependent and T-independent carriers.
J Exp Med. 1978 Jun 1;147(6):1824-31. doi: 10.1084/jem.147.6.1824.
2
Concanavalin A supernatant recruits antigen-insensitive IgG memory B lymphocyte precursors into an antigen-sensitive precursor pool.
J Immunol. 1982 Feb;128(2):720-5.
3
Generation of immune memory by haptenated derivatives of thymus-independent antigens in C57BL/6 mice. I. The differentiation of memory B lymphocytes into antibody-secreting cells depends on the nature of the thymus-independent carrier used for memory induction and/or revelation.
Cell Immunol. 1983 Jan;75(1):52-62. doi: 10.1016/0008-8749(83)90304-0.
4
5
Epitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responses.
J Exp Med. 1982 Jun 1;155(6):1730-40. doi: 10.1084/jem.155.6.1730.
6
Immunopotentiation by SGP and Quil A. II. Identification of responding cell populations.
Cell Immunol. 1986 Apr 15;99(1):128-39. doi: 10.1016/0008-8749(86)90222-4.
7
T cell dependent and independent steps in IgE-B memory cell development.
Int Arch Allergy Appl Immunol. 1980;63(3):284-93. doi: 10.1159/000232638.
8
B cell memory to thymus-independent antigens type 1 and type 2: the role of lipopolysaccharide in B memory induction.
Eur J Immunol. 1988 Sep;18(9):1417-24. doi: 10.1002/eji.1830180918.
9
Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory.
Immunology. 1979 Oct;38(2):291-9.
10
Selective roles of thymus-derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specific IgM and IgG antibody responses.
J Exp Med. 1974 Jul 1;140(1):239-52. doi: 10.1084/jem.140.1.239.
引用本文的文献
1
Innate B cell helpers reveal novel types of antibody responses.
Nat Immunol. 2013 Feb;14(2):119-26. doi: 10.1038/ni.2511. Epub 2013 Jan 18.
2
Immunological features of psoriasis. Effects of Ro-109359, concanavalin A, pokeweed mitogen, and methotrexate on cultivated lymphocytes.
Arch Dermatol Res. 1981;271(1):29-40. doi: 10.1007/BF00417385.
3
Antigen requirements for priming of IgG producing B memory cells specific for Type III pneumococcal polysaccharide.
Immunology. 1980 Aug;40(4):521-7.
4
Cyclic development of immunological memory to bacterial lipopolysaccharide.
Infect Immun. 1985 Apr;48(1):1-6. doi: 10.1128/iai.48.1.1-6.1985.
5
Regulation of IgG memory responses by helper and suppressor T cells activated by the type 2 antigen, polyvinylpyrrolidone.
J Exp Med. 1985 Jun 1;161(6):1357-67. doi: 10.1084/jem.161.6.1357.
6
Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory.
Immunology. 1979 Oct;38(2):291-9.
本文引用的文献
1
Immunization of dissociated spleen cell cultures from normal mice.
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
3
Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide.
Cell Immunol. 1971 Oct;2(5):411-24. doi: 10.1016/0008-8749(71)90052-9.
4
5
Thymus cell population exerting a regulatory function in the immune response of mice to polyvinyl pyrrolidone.
Cell Immunol. 1974 Jul;13(1):76-86. doi: 10.1016/0008-8749(74)90228-7.
6
Evidence for readily induced tolerance to heterologous erythrocytes in nude mice.
Scand J Immunol. 1974;3(1):39-49. doi: 10.1111/j.1365-3083.1974.tb01231.x.
7
A rapid method for the isolation of functional thymus-derived murine lymphocytes.
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
8
Effects of antilymphocyte serum on thymic independent immunity. 1. Lack of immunosuppressive action on the antibody response to E. coli lipopolysaccharide.
Cell Immunol. 1973 Jun;7(3):380-8. doi: 10.1016/0008-8749(73)90202-5.
9
Immunological B memory in thymus deprived mice.
Nat New Biol. 1972 Sep 13;239(89):63-4. doi: 10.1038/newbio239063a0.
10
Strain differences in the antibody plaque-forming cell responses of inbred mice to pneumococcal polysaccharide.
Cell Immunol. 1971 Feb;2(1):73-81. doi: 10.1016/0008-8749(71)90026-8.
Zotero 插件