定制单克隆抗体。
Tailor-made monoclonal antibodies.
作者信息
DePinho R A, Feldman L B, Scharff M D
出版信息
Ann Intern Med. 1986 Feb;104(2):225-33. doi: 10.7326/0003-4819-104-2-225.
PMID:3080934
Abstract
Monoclonal antibodies, potentially powerful diagnostic and therapeutic reagents, are having a significant impact in basic and clinical research. Some persisting problems must be solved, however, in order to realize the potential of this technology. We review the basic biology of antibody molecules and the genes that encode them, and discuss how this knowledge can be applied to make more effective monoclonal antibodies.
摘要
单克隆抗体作为具有潜在强大功能的诊断和治疗试剂，正在基础研究和临床研究中产生重大影响。然而，为了实现这项技术的潜力，一些持续存在的问题必须得到解决。我们回顾了抗体分子及其编码基因的基础生物学，并讨论了如何应用这些知识来制备更有效的单克隆抗体。
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