流感疫苗接种诱导 NK 细胞介导的 II 型 IFN 反应，以 IL-6 依赖的方式调节体液免疫。
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner.
机构信息
Institute for Research in Biomedicine (IRB), Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland; Graduate School of Cellular and Molecular Sciences, Faculty of Medicine, University of Bern, 3012 Bern, Switzerland.
Institute for Research in Biomedicine (IRB), Università della Svizzera italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
出版信息
Cell Rep. 2019 Feb 26;26(9):2307-2315.e5. doi: 10.1016/j.celrep.2019.01.104.
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of the LN and become activated by type I interferons (IFNs) produced by LN macrophages. The activation of NK cells leads to their early production of IFNγ, which in turn regulates the recruitment of IL-6+ CD11b+ dendritic cells. Finally, we demonstrate that the interleukin-6 (IL-6)-mediated inflammation is important for the development of an effective humoral response against influenza virus in the draining LN.
自然杀伤 (NK) 细胞在针对疫苗的免疫反应中的作用尚未完全阐明。在这里，我们研究了浸润性 NK 细胞在引发引流淋巴结 (LN) 中灭活流感病毒疫苗触发的炎症反应中的功能。我们观察到，接种疫苗后，NK 细胞被募集到 LN 的滤泡间和髓质区，并被 LN 巨噬细胞产生的 I 型干扰素 (IFN) 激活。NK 细胞的激活导致其早期产生 IFNγ，进而调节 IL-6+CD11b+树突状细胞的募集。最后，我们证明白细胞介素-6 (IL-6) 介导的炎症对于在引流 LN 中针对流感病毒产生有效的体液反应很重要。
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