Husby G, Williams R C, Ramirez F, Tung K S
Clin Immunol Immunopathol. 1986 Apr;39(1):68-80. doi: 10.1016/0090-1229(86)90206-0.
Frozen kidney biopsy sections from nine patients with systemic lupus erythematosus (SLE) as well as many other renal diseases, including IgA nephropathy, membranous nephritis, and minimal change nephrotic syndrome, were negative for interferons -alpha and -gamma by immunofluorescence. Lupus patients studied included several subjects with marked serum elevations of interferon activity as well as others with low or negative serum interferon levels. Isolated glomerular eluates prepared from normal and SLE kidneys showed no functional interferon activity by virus plaque inhibition assay. Components of normal as well as SLE serum showed no direct binding to interferon -alpha or -gamma by ELISA assays.
对9例系统性红斑狼疮（SLE）患者以及许多其他肾脏疾病患者（包括IgA肾病、膜性肾病和微小病变肾病综合征）的冰冻肾活检切片进行免疫荧光检测，结果显示α干扰素和γ干扰素均为阴性。所研究的狼疮患者包括几名血清干扰素活性显著升高的受试者以及其他血清干扰素水平较低或呈阴性的受试者。通过病毒蚀斑抑制试验，从正常肾脏和SLE肾脏制备的分离肾小球洗脱液未显示出功能性干扰素活性。通过ELISA检测，正常血清和SLE血清的成分均未显示与α干扰素或γ干扰素直接结合。
