Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Mater Sci Eng C Mater Biol Appl. 2019 May;98:1014-1021. doi: 10.1016/j.msec.2019.01.065. Epub 2019 Jan 16.
The application of MCM-41 functionalized by 12-tungstophosphoric acid (TPA) as drug carrier for cancer treatment was studied by loading of camptothecin (CPT). In-vitro controlled release study of CPT in Simulated Body Fluid (pH 7.4, 37 °C) was carried out under stirring as well as static conditions. The systems were also evaluated on cancer cells (HepG2) and the carriers are found to be non-toxic to the cancer cells. In order to see the influence of inorganic moiety on release rate of drug, study was also carried out with CPT loaded unfunctionalized MCM-41. A detailed study on release kinetics and release mechanism using First Order Release Kinetic Model, Higuchi Model, Koresmeyer-Pepps Model and Extended kinetic model was also carried out.
研究了用 12-钨磷酸（TPA）功能化的 MCM-41 作为载体制备喜树碱（CPT）的应用，以用于癌症治疗。在搅拌和静态条件下，在模拟体液（pH 7.4，37°C）中进行了 CPT 的体外控制释放研究。还在肝癌细胞（HepG2）上评估了这些系统，发现载体对癌细胞无毒。为了观察无机部分对药物释放速率的影响，还进行了载有未功能化 MCM-41 的 CPT 的研究。还使用一级释放动力学模型、Higuchi 模型、Koresmeyer-Pepps 模型和扩展动力学模型对释放动力学和释放机制进行了详细研究。
