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预测尼泊尔部分选定地区慢性病老年人群体居家药物管理实践的因素。

Factors predicting home medication management practices among chronically ill older population of selected districts of Nepal.

机构信息

Department of Pharmacy, Shree Medical and Technical College, Main Block, Bharatpur-12, Chitwan, Nepal.

School of Pharmacy, University of Queensland, Brisbane, QLD, Australia.

出版信息

BMC Geriatr. 2019 Feb 27;19(1):55. doi: 10.1186/s12877-019-1081-7.

Abstract

BACKGROUND

Older population often have multiple and complex needs that are consequently challenged by the presence of polypharmacy, adverse drug reactions and drug-drug interaction. We aimed to determine home medication management practices (MMP) and its associated factors among chronically ill older population of selected districts of Nepal.

METHODS

A community based cross-sectional survey was conducted among 386 chronically ill older individuals from selected areas of Nepal between April to September 2016. Appropriateness of MMP was assessed through scores of questions using interview method. Multivariate logistic regression analysis using potential variables from bivariate analysis were used to determine factors affecting MMP.

RESULTS

The overall home MMP was mostly inappropriate (80.1%). Most participants had multiple prescribers for single disease (202, 52.3%) and inappropriate medication storage (188, 48.7%). Though the majority of them had drug administration schedule (378, 97.9%), expired medicines were also used (2, 0.5%). Regression analysis showed less than one year duration of disease (odds ratio [OR] = 3.901, 95% confidence interval [CI] = 1.528 to 9.959, P = 0.004), 1-2 years duration of disease (OR = 2.415, 95% CI = 1.210 to 4.821, P = 0.012) and smokers (OR = 2.025, 95% CI = 1.036 to 3.956, P = 0.039) as the major factors affecting appropriate home MMP.

CONCLUSIONS

The home MMP was associated with duration of disease and smoking status among chronically ill older patients living in selected districts of Nepal. Proper counselling and monitoring of such patients might be necessary to improve the practice.

摘要

背景

老年人群往往有多种复杂的需求,而这些需求因同时使用多种药物、药物不良反应和药物相互作用而受到挑战。我们旨在确定尼泊尔选定地区慢性病老年人群的家庭药物管理实践(MMP)及其相关因素。

方法

2016 年 4 月至 9 月期间,在尼泊尔选定地区对 386 名慢性病老年患者进行了一项基于社区的横断面调查。通过访谈方法,使用问题得分来评估 MMP 的适宜性。使用来自双变量分析的潜在变量进行多变量逻辑回归分析,以确定影响 MMP 的因素。

结果

总体而言,家庭 MMP 大多不适当(80.1%)。大多数患者患有单一疾病的多个处方(202 例,52.3%)和不适当的药物储存(188 例,48.7%)。尽管他们大多数人都有药物给药时间表(378 例,97.9%),但也使用了过期药物(2 例,0.5%)。回归分析显示,疾病持续时间少于 1 年(比值比[OR] = 3.901,95%置信区间[CI] = 1.528 至 9.959,P = 0.004)、1-2 年(OR = 2.415,95% CI = 1.210 至 4.821,P = 0.012)和吸烟者(OR = 2.025,95% CI = 1.036 至 3.956,P = 0.039)是影响适当家庭 MMP 的主要因素。

结论

在尼泊尔选定地区生活的慢性病老年患者中,家庭 MMP 与疾病持续时间和吸烟状况有关。可能需要对这些患者进行适当的咨询和监测,以改善实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f02/6391813/231888241886/12877_2019_1081_Fig1_HTML.jpg

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