Dai Weiying, Duan Wenna, Alfaro Freddy J, Gavrieli Anna, Kourtelidis Fotini, Novak Vera
Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, USA.
Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, USA.
Neurobiol Aging. 2017 Dec;60:192-202. doi: 10.1016/j.neurobiolaging.2017.09.004. Epub 2017 Sep 14.
We investigated the relationships between cerebral blood flow (CBF), cognitive, and mobility decline in type 2 diabetes mellitus (T2DM) over a 2-year period. Seventy-three participants (41 T2DM and 32 controls) were evaluated using volumetric CBF with arterial spin labeling perfusion magnetic resonance imaging at baseline and at the 2-year follow-up. Regions with significant CBF differences between T2DM participants and controls at baseline were detected using voxel-wise analysis. Correlation analysis was performed to investigate the association between regional CBF and cognitive or mobility performance over the 2-year span. Compared to controls, participants with T2DM had decreased CBF in the resting-state default mode, visual, and cerebellum networks. Greater decrease in longitudinal CBF values at these regions over a 2-year span was associated with worse gait, memory and executive functions, and higher baseline insulin resistance and worse baseline cognitive performance. In T2DM, impairment of resting regional perfusion is closely related to worse cognitive and mobility performance. Insulin resistance may further contribute to regional perfusion deficit in T2DM.
我们调查了2型糖尿病（T2DM）患者在2年期间脑血流量（CBF）、认知功能和运动功能衰退之间的关系。73名参与者（41名T2DM患者和32名对照者）在基线期和2年随访期使用动脉自旋标记灌注磁共振成像的容积CBF进行评估。通过体素分析检测T2DM参与者与对照者在基线期CBF存在显著差异的区域。进行相关性分析以研究2年期间区域CBF与认知或运动功能表现之间的关联。与对照者相比，T2DM参与者在静息状态默认模式、视觉和小脑网络中的CBF降低。在2年期间这些区域纵向CBF值的更大降低与更差的步态、记忆和执行功能，以及更高的基线胰岛素抵抗和更差的基线认知表现相关。在T2DM中，静息区域灌注受损与更差的认知和运动功能表现密切相关。胰岛素抵抗可能进一步导致T2DM患者区域灌注不足。
