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患有慢性健康状况的幼儿中白喉-破伤风-百日咳、麻疹-腮腺炎-风疹和脊髓灰质炎疫苗的完整性和及时性:系统评价。

Completeness and timeliness of diphtheria-tetanus-pertussis, measles-mumps-rubella, and polio vaccines in young children with chronic health conditions: A systematic review.

机构信息

Queen's University, Kingston, ON, Canada.

Dalhousie University, Halifax, NS, Canada; Canadian Centre for Vaccinology, Halifax, NS, Canada.

出版信息

Vaccine. 2019 Mar 22;37(13):1725-1735. doi: 10.1016/j.vaccine.2019.02.031. Epub 2019 Feb 25.

DOI:10.1016/j.vaccine.2019.02.031
PMID:30814030
Abstract

OBJECTIVE

To systematically review literature on uptake and timeliness of diphtheria-tetanus-pertussis, measles-mumps-rubella, and/or polio-containing vaccines ininfants who were born preterm, with a low birth weight, and/or with chronic health conditions that were diagnosed within the first 6 months of life.

METHODS

Using a standardized search strategy developed by a medical librarian, records were extracted from MEDLINE, Embase, Database of Abstracts of Reviews of Effects, and CINAHL up to May 8, 2018.

RESULTS

Out of the 1997 records that were screened, we identified 21 studies that met inclusion criteria. Eleven studies assessed vaccine coverage and/or timeliness in preterm infants, 6 in low birth weight infants, and 7 in children with chronic health conditions. Estimates of coverage in these populations were highly variable, ranging from 40% to 100% across the vaccines and population groups.

CONCLUSIONS

There is a lack of studies reporting coverage and timeliness of routine immunizations in special populations of children.

POLICY IMPLICATIONS

Our review suggests a need for improved surveillance of immunization status in special populations of infants, as wellas aneed for standardization of reporting practices.

摘要

目的

系统评价在婴儿期被诊断出患有早产、低出生体重和/或慢性健康状况的情况下,及时接种含白喉、破伤风、百日咳、麻疹、腮腺炎、风疹和/或脊髓灰质炎疫苗的文献。

方法

使用医学图书馆员制定的标准化搜索策略,从 MEDLINE、Embase、效应摘要数据库和 CINAHL 中提取截至 2018 年 5 月 8 日的记录。

结果

在筛选出的 1997 条记录中,我们确定了 21 项符合纳入标准的研究。11 项研究评估了早产儿的疫苗覆盖率和/或及时性,6 项研究评估了低出生体重儿的疫苗覆盖率和/或及时性,7 项研究评估了患有慢性健康状况儿童的疫苗覆盖率和/或及时性。这些人群的疫苗覆盖率估计差异很大,在疫苗和人群组之间的范围从 40%到 100%不等。

结论

缺乏报告特殊人群儿童常规免疫接种覆盖率和及时性的研究。

政策意义

我们的综述表明,需要加强对特殊人群婴儿免疫状况的监测,同时需要标准化报告做法。

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