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会阴样秃发:一例报告

Perinevoid Alopecia: A Case Report.

作者信息

Ruiz-Arriaga León Felipe, López-García Lirio, Vega-Memije María Elisa

机构信息

Department of Dermatopathology, "Dr. Manuel Gea González" General Hospital, Mexico City, Mexico.

Dermatologist, Private Practice, Hospital Ángeles del Pedregal, Mexico City, Mexico.

出版信息

Skin Appendage Disord. 2019 Feb;5(2):94-96. doi: 10.1159/000490469. Epub 2018 Jul 18.

DOI:10.1159/000490469
PMID:30815441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6388562/
Abstract

Perinevoid alopecia has been described as an associated alopecia surrounding a pigmented nevus due to an inflammatory response against nevus structures. It is described as a part of other nevocentric phenomena in which a cellular inflammatory response against nevus antigens develops. A 35-year-old male presented with a unique area of non-scarring alopecia surrounding an asymptomatic, pigmented nevus with a 1-month evolution. Trichoscopic and histologic findings were compatible with alopecia areata (AA). One month after excision, hair regrowth was reported by the patient. We concluded that perinevoid alopecia is an extremely rare clinical presentation of AA associated with a central, pigmented nevus where a cellular inflammatory response is triggered against hair follicles, nevoid cells, and melanocytic structures.

摘要

阴部样秃发被描述为由于针对痣结构的炎症反应而围绕色素痣的一种相关秃发。它被描述为其他以痣为中心的现象的一部分,其中会发生针对痣抗原的细胞炎症反应。一名35岁男性出现一个独特的非瘢痕性秃发区域,该区域围绕着一个无症状的色素痣,病程1个月。皮肤镜和组织学检查结果与斑秃(AA)相符。切除术后1个月,患者报告毛发再生。我们得出结论,阴部样秃发是AA的一种极其罕见的临床表现,与中央色素痣相关,在此情况下会触发针对毛囊、痣细胞和黑素细胞结构的细胞炎症反应。

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引用本文的文献

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Enhancing hair regrowth in Alopecia areata: the power duo of CO2 fractional laser and Bimatoprost.促进斑秃毛发再生:二氧化碳点阵激光与比马前列素的强强组合
Arch Dermatol Res. 2025 Apr 19;317(1):723. doi: 10.1007/s00403-025-04183-1.
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Epidemiological, Clinical, Dermoscopic Findings, and Management of Perinevoid Alopecia.类痣样秃发的流行病学、临床、皮肤镜表现及治疗
Dermatol Pract Concept. 2025 Jan 30;15(1):4742. doi: 10.5826/dpc.1501a4742.
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Perinevoid Alopecia: an Unusual Presentation of Alopecia Areata.阴部样秃发:斑秃的一种不寻常表现。
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本文引用的文献

1
Throwing Light onto the Core of a Halo Nevus: A New Finding.揭示晕痣的核心:一项新发现。
Indian J Dermatol. 2016 Mar-Apr;61(2):238. doi: 10.4103/0019-5154.177801.
2
Melanocytes: a possible autoimmune target in alopecia areata.黑素细胞:斑秃中一个可能的自身免疫靶点。
J Am Acad Dermatol. 2009 Sep;61(3):529-30. doi: 10.1016/j.jaad.2009.01.017.
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Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice.黑素细胞相关的T细胞表位可作为自身抗原,将斑秃转移至Prkdc(scid)小鼠的人头皮外植体上。
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Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?斑秃是针对生长期毛囊球部异常的MHC I类分子表达所暴露的黑素生成相关蛋白的自身免疫反应吗?
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Perinevoid alopecia. An unusual variety of alopecia areata.
Arch Dermatol. 1976 Oct;112(10):1432-4. doi: 10.1001/archderm.112.10.1432.