Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 465 21st Ave. S., MRBIII Room 6140B, Nashville, TN, 37240, USA.
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
J Autism Dev Disord. 2020 Jun;50(6):2208-2216. doi: 10.1007/s10803-019-03942-0.
The prevalence of ASD remains relatively stable across the lifespan, necessitating a quantitative understanding of how intervention clinical research is applied across age groups. Here we report a systematic review of treatment studies between 2013 and 2017, enrolling 11,213 subjects with ASD in 218 studies. Individuals under 18 years old constituted the majority of studies (84%) and subjects (92%). Subjects under 18 years old were more likely to be enrolled in behavioral studies (OR (CI) = 1.34 (1.17-1.54)), and less likely to be enrolled in pharmacological (OR = 0.60 (0.52-0.69)) studies than subjects ≥ 18 years old. Identified disparities in both intervention modalities and outcome measures should serve to guide future research priorities.
自闭症谱系障碍（ASD）的患病率在整个生命周期中相对稳定，因此需要定量了解干预临床研究在不同年龄组中的应用情况。在这里，我们报告了一项对 2013 年至 2017 年期间的治疗研究的系统回顾，该研究共纳入了 218 项研究中的 11213 名 ASD 患者。年龄在 18 岁以下的个体构成了大多数研究（84%）和受试者（92%）。年龄在 18 岁以下的受试者比年龄在 18 岁及以上的受试者更有可能被纳入行为研究（OR（CI）=1.34（1.17-1.54）），而不太可能被纳入药物研究（OR=0.60（0.52-0.69））。干预方式和结果测量方面存在的差异应有助于指导未来的研究重点。
