Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
John Moores University, Liverpool, UK.
Muscle Nerve. 2019 Jun;59(6):717-725. doi: 10.1002/mus.26460. Epub 2019 Mar 25.
Controversy exists over the effects of functional electrical stimulation (FES) on reinnervation. We hypothesized that intramuscular FES would not delay reinnervation after recurrent laryngeal nerve (RLn) axonotmesis.
RLn cryo-injury and electrode implantation in ipsilateral posterior cricoarytenoid muscle (PCA) were performed in horses. PCA was stimulated for 20 weeks in eight animals; seven served as controls. Reinnervation was monitored through muscle response to hypercapnia, electrical stimulation and exercise. Ultimately, muscle fiber type proportions and minimum fiber diameters, and RLn axon number and degree of myelination were determined.
Laryngeal function returned to normal in both groups within 22 weeks. FES improved muscle strength and geometry, and induced increased type I:II fiber proportion (p = 0.038) in the stimulated PCA. FES showed no deleterious effects on reinnervation.
Intramuscular electrical stimulation did not delay PCA reinnervation after axonotmesis. FES can represent a supportive treatment to promote laryngeal functional recovery after RLn injury. Muscle Nerve 59:717-725, 2019.
功能性电刺激（FES）对神经再支配的影响存在争议。我们假设，在喉返神经（RLn）轴索切断后，肌内 FES 不会延迟神经再支配。
对马的 RLn 冷冻损伤和同侧环杓后肌（PCA）电极植入进行了研究。在 8 只动物中进行了 20 周的 PCA 刺激；7 只作为对照。通过肌肉对高碳酸血症、电刺激和运动的反应来监测再支配情况。最终，确定了肌纤维类型比例和最小纤维直径，以及 RLn 轴突数量和髓鞘程度。
两组的喉功能均在 22 周内恢复正常。FES 改善了肌肉力量和几何形状，并诱导刺激 PCA 中 I 型：II 型纤维比例增加（p = 0.038）。FES 对再支配没有不良影响。
肌内电刺激不会延迟 PCA 轴索切断后的再支配。FES 可以作为一种支持性治疗方法，促进 RLn 损伤后喉功能的恢复。肌肉神经 59:717-725，2019 年。
