Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.
University of Oslo, Oslo, Norway.
Acta Ophthalmol. 2019 Nov;97(7):695-699. doi: 10.1111/aos.14028. Epub 2019 Feb 28.
To study the incidence, aetiology, pathogenic causes, treatment and visual outcomes of endophthalmitis (EO) at the Department of Ophthalmology, Oslo University Hospital (OUS), Norway.
Retrospective registry study. Medical records of all EO patients treated at OUS over a 2-year period were reviewed.
The study identified 46 EO eyes of 44 patients; 19 eyes had postcataract surgery EO (PCE), and 6 eyes had postinjection EO (PIE). Of 4778 primary cataract surgeries performed at OUS, there was one PCE (incidence 0.21 per 1000; 95% CI 0.04-1.19 per 1000). Of 38 134 intravitreal injections performed at OUS, there were 3 PIE (incidence 0.08 per 1000; 95% CI 0.03-0.23 per 1000). Among 15 751 cataract surgeries performed at other ophthalmic centres in Oslo and Akershus County (OOC), there were 15 PCE (incidence 0.95 per 1000; 95% CI 0.58-1.57 per 1000). Of 3000 intravitreal injections performed at OOC, there was one PIE (incidence 0.33 per 1000; 95% CI 0.059-1.89 per 1000). For neither PCE nor PIE, there were significant differences in odds ratios between OUS and OOC. The odds ratio for PCE versus PIE was, however, 8.0 (95% CI 2.7-24.0; p < 0.001). Cultures were positive in 35 of 46 eyes (76%). The most common pathogen was Staphylococcus epidermidis. Twenty-two eyes (48%) achieved a clinically significant improvement in visual function (≥0.3 logMAR) following treatment.
The overall risk of PCE and PIE was low. It was, however, higher for PCE than PIE, probably reflecting the relative difference in invasiveness between the procedures.
研究挪威奥斯陆大学医院（OUS）眼科发生的眼内炎（EO）的发病率、病因、发病机制、治疗和预后。
回顾性登记研究。对 OUS 过去两年内接受治疗的所有 EO 患者的病历进行了回顾。
本研究共纳入 44 例 46 只眼的 EO 患者，其中 19 只眼为白内障术后眼内炎（PCE），6 只眼为眼内注射后眼内炎（PIE）。在 OUS 进行的 4778 例原发性白内障手术中，有 1 例 PCE（发病率为 0.21/1000；95%CI：0.04-1.19/1000）。在 OUS 进行的 38134 例玻璃体腔内注射中，有 3 例 PIE（发病率为 0.08/1000；95%CI：0.03-0.23/1000）。在奥斯陆和阿克什胡斯郡（OOC）的其他眼科中心进行的 15751 例白内障手术中，有 15 例 PCE（发病率为 0.95/1000；95%CI：0.58-1.57/1000）。在 OOC 进行的 3000 例玻璃体腔内注射中，有 1 例 PIE（发病率为 0.33/1000；95%CI：0.059-1.89/1000）。无论是 PCE 还是 PIE，OUS 和 OOC 的比值比均无显著差异。然而，PCE 与 PIE 的比值比为 8.0（95%CI：2.7-24.0；p<0.001）。46 只眼中有 35 只（76%）的培养结果为阳性。最常见的病原体是表皮葡萄球菌。22 只眼（48%）在治疗后视力功能（≥0.3 logMAR）得到了有临床意义的改善。
PCE 和 PIE 的总体风险较低。然而，PCE 高于 PIE，可能反映了两种手术的相对侵袭性差异。
