Clayberger C, Dyer B, McIntyre B, Koller T D, Hardy B, Parham P, Lanier L L, Krensky A M
J Immunol. 1986 Mar 1;136(5):1537-41.
Natural killer (NK) cell have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.
自然杀伤（NK）细胞已被证明参与对肿瘤和病毒抗原的免疫反应。我们在此描述一种单克隆抗体，抗-KC-1，它可阻断新鲜NK细胞而非活化NK细胞对NK靶标的裂解作用。抗-KC-1对细胞毒性T淋巴细胞活性或抗体依赖性细胞毒性没有影响。该抗体可能有助于分析NK细胞的活化及裂解机制。
