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SPEG, an Indispensable Kinase of SERCA2a for Calcium Homeostasis.

作者信息

Kusumoto Dai, Yuasa Shinsuke, Fukuda Keiichi

机构信息

From the Department of Cardiology (D.K., S.Y., K.F.), Keio University School of Medicine, Tokyo, Japan.

Department of Emergency and Critical Care Medicine (D.K.), Keio University School of Medicine, Tokyo, Japan.

出版信息

Circ Res. 2019 Mar;124(5):668-670. doi: 10.1161/CIRCRESAHA.119.314678.

DOI:10.1161/CIRCRESAHA.119.314678
PMID:30817253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6407822/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6407822/d0f5032ab211/res-124-668-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6407822/d0f5032ab211/res-124-668-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7673/6407822/d0f5032ab211/res-124-668-g001.jpg

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本文引用的文献

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SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain.SPEG 通过其第二激酶结构域调控 SERCA2a 从而控制肌浆网内钙离子重摄取。
Circ Res. 2019 Mar;124(5):712-726. doi: 10.1161/CIRCRESAHA.118.313916.
2
SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.SPEG（横纹肌优先表达蛋白激酶）通过调节连接膜复合体活性对心脏功能至关重要。
Circ Res. 2017 Jan 6;120(1):110-119. doi: 10.1161/CIRCRESAHA.116.309977. Epub 2016 Oct 11.
3
Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial.
经皮基因治疗增强心脏病患者的钙水平（CUPID 2）：一项随机、多中心、双盲、安慰剂对照、2b 期试验。
Lancet. 2016 Mar 19;387(10024):1178-86. doi: 10.1016/S0140-6736(16)00082-9. Epub 2016 Jan 21.
4
SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.SPEG与肌管素相互作用，其缺乏会导致伴有扩张型心肌病的中央核性肌病。
Am J Hum Genet. 2014 Aug 7;95(2):218-26. doi: 10.1016/j.ajhg.2014.07.004. Epub 2014 Jul 31.
5
Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy.改变的肌浆网钙循环——心力衰竭治疗的靶点。
Nat Rev Cardiol. 2012 Dec;9(12):717-33. doi: 10.1038/nrcardio.2012.145. Epub 2012 Oct 23.
6
SUMO1-dependent modulation of SERCA2a in heart failure.SUMO1 依赖性调节心力衰竭中的 SERCA2a。
Nature. 2011 Sep 7;477(7366):601-5. doi: 10.1038/nature10407.
7
Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy.长期心脏靶向RNA干扰治疗心力衰竭可恢复心脏功能并减轻病理性肥大。
Circulation. 2009 Mar 10;119(9):1241-52. doi: 10.1161/CIRCULATIONAHA.108.783852. Epub 2009 Feb 23.
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Biochemistry. 2009 Mar 24;48(11):2411-21. doi: 10.1021/bi8021526.
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