（前）肾素受体：高血压和代谢综合征的一个新兴参与者。
The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome.
机构信息
Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA; Salt Lake Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
出版信息
Kidney Int. 2019 May;95(5):1041-1052. doi: 10.1016/j.kint.2018.10.042. Epub 2019 Feb 26.
Abstract
The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/ß catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.
摘要
（前）肾素受体（PRR）是一种多功能蛋白，在多个器官中表达。前肾素/肾素与 PRR 的结合激活了血管紧张素 II 依赖性和非依赖性途径。PRR 还参与自噬和 Wnt/β连环蛋白信号通路，这些功能不依赖于前肾素结合。新出现的证据表明，PRR 在血压调节以及葡萄糖和脂质代谢中发挥重要作用。本文综述了 PRR 在健康和疾病中的作用，特别强调了高血压和代谢综合征。
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