Genetic loss of alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia.
作者信息
Stagg David B, Whittlesey Rebecca L, Li Xiuqi, Lozovatsky Larisa, Gardenghi Sara, Rivella Stefano, Finberg Karin E
机构信息
Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA.
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA.
出版信息
Haematologica. 2019 Oct;104(10):e442-e446. doi: 10.3324/haematol.2018.213371. Epub 2019 Feb 28.
Abstract
摘要
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Genetic loss of alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia.在中间型β地中海贫血小鼠模型中，[基因名称缺失]的遗传缺失改变了终末红细胞分化。
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本文引用的文献
1
mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.信使核糖核酸（mRNA）和血浆铁调素水平受性别和品系影响，但无法预测近交系小鼠的组织铁水平。
Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G511-G523. doi: 10.1152/ajpgi.00307.2016. Epub 2017 Aug 10.
2
Erythroferrone and matriptase-2 independently regulate hepcidin expression.红细胞生成素铁调素和胃蛋白酶2分别独立调节铁调素的表达。
Am J Hematol. 2017 May;92(5):E61-E63. doi: 10.1002/ajh.24672. Epub 2017 Feb 24.
3
Ineffective erythropoiesis and regulation of iron status in iron loading anaemias.铁过载性贫血中无效的红细胞生成和铁状态的调节。
Br J Haematol. 2016 Feb;172(4):512-23. doi: 10.1111/bjh.13820. Epub 2015 Oct 22.
4
Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging.红细胞氧化应激会损害氧气输送并诱导红细胞衰老。
Front Physiol. 2014 Feb 28;5:84. doi: 10.3389/fphys.2014.00084. eCollection 2014.
5
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.降低 TMPRSS6 可改善小鼠的血色病和β地中海贫血。
J Clin Invest. 2013 Apr;123(4):1531-41. doi: 10.1172/JCI66969. Epub 2013 Mar 25.
6
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.一种靶向 Tmprss6 的 RNAi 疗法可降低 Hfe(-/-) 小鼠的铁过载，并改善中间型 β-地中海贫血小鼠的贫血和铁过载。
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7
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.TMPRSS6 缺失可减轻β-地中海贫血小鼠模型的表型。
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