三阴乳腺癌中**和**基因拷贝数改变的重要性。 注：原文中“Importance of Copy Number Alterations of and Genes”里两个“and”之间缺少具体基因名称，我按照原文直接翻译，但此处可能有信息缺失。
Importance of Copy Number Alterations of and Genes in Triple Negative Breast Cancer.
作者信息
Nedeljković Milica, Tanić Nikola, Dramićanin Tatjana, Milovanović Zorka, Šušnjar Snežana, Milinković Vedrana, Vujović Ivana, Prvanović Mirjana, Tanić Nasta
机构信息
Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.
Institute for Biological Research »Siniša Stanković«, University of Belgrade, Belgrade, Serbia.
出版信息
J Med Biochem. 2019 Mar 1;38(1):63-70. doi: 10.2478/jomb-2018-0012. eCollection 2019 Mar.
BACKGROUND
Triple negative breast cancer (TNBC) is characterized by aggressive clinical course and is unresponsive to anti-HER2 and endocrine therapy. TNBC is difficult to treat and is often lethal. Given the need to find new targets for therapy we explored clinicopathological significance of copy number gain of and . Our aim was to determine the impact of and copy number gain on clinical course and outcome of TNBC.
METHODS
and gene copy number alterations were evaluated in 78 archive TNBC samples using TaqMan based quantitative real time PCR assays.
RESULTS
50% of samples had increased copy number. copy number gain was associated with TNBC in contrast to ER positive cancers. Our results showed significant correlation between copy number gain and high grade of TNBCs. This suggests that copy number could be an useful prognostic marker for TNBC patients. copy number gain was associated with high pTNM stage as well as lobular and medullary tumor subtypes. 43% of samples had increased copy number. No correlations between copy number gain and clinicopathological variables were observed.
CONCLUSIONS
We identified copy number gain as a prognostic marker for TNBC. Our results indicate that may contribute to TNBC progression. We observed no significant association between and/or copy number status and patient survival.
背景
三阴性乳腺癌（TNBC）具有侵袭性临床病程，对抗HER2和内分泌治疗无反应。TNBC难以治疗且往往致命。鉴于需要寻找新的治疗靶点，我们探讨了[基因名称1]和[基因名称2]拷贝数增加的临床病理意义。我们的目的是确定[基因名称1]和[基因名称2]拷贝数增加对TNBC临床病程和预后的影响。
方法
使用基于TaqMan的定量实时PCR分析评估78份存档TNBC样本中的[基因名称1]和[基因名称2]基因拷贝数改变。
结果
50%的样本[基因名称1]拷贝数增加。与雌激素受体（ER）阳性癌症相比，[基因名称1]拷贝数增加与TNBC相关。我们的结果显示[基因名称1]拷贝数增加与TNBC的高级别显著相关。这表明[基因名称1]拷贝数可能是TNBC患者有用的预后标志物。[基因名称1]拷贝数增加与高pTNM分期以及小叶和髓样肿瘤亚型相关。43%的样本[基因名称2]拷贝数增加。未观察到[基因名称2]拷贝数增加与临床病理变量之间的相关性。
结论
我们确定[基因名称1]拷贝数增加是TNBC的预后标志物。我们的结果表明[基因名称1]可能促进TNBC进展。我们未观察到[基因名称2]和/或[基因名称1]拷贝数状态与患者生存之间的显著关联。
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