一种术后疼痛的小鼠模型。
A Mouse Model of Postoperative Pain.
作者信息
Cowie Ashley M, Stucky Cheryl L
机构信息
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
出版信息
Bio Protoc. 2019 Jan 20;9(2). doi: 10.21769/BioProtoc.3140.
Abstract
Postoperative pain is highly debilitating and hinders recovery. Opioids are the main pain medication used for acute postoperative pain. Given the devastating opioid addiction and overdose epidemic across the US, non-opioid pain therapeutics are desperately needed. In order to develop novel, non-opioid therapies for the treatment of postoperative pain and identify the mechanisms underlying this pain, rodent models of incisional pain have been established. The protocol herein describes in detail how to create a mouse model of postoperative pain that was adapted from established protocols. This model of postoperative pain is frequently-used, highly reproducible, and results in peripheral and central nervous system alterations.
摘要
术后疼痛极具致残性，会阻碍恢复。阿片类药物是用于急性术后疼痛的主要止痛药物。鉴于美国各地阿片类药物成瘾和过量使用的灾难性流行情况，非阿片类疼痛治疗方法迫切需要。为了开发用于治疗术后疼痛的新型非阿片类疗法并确定这种疼痛的潜在机制，已经建立了切口疼痛的啮齿动物模型。本文所述方案详细描述了如何创建一种改编自既定方案的术后疼痛小鼠模型。这种术后疼痛模型经常被使用，具有高度可重复性，并会导致外周和中枢神经系统改变。
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