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New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone.
Am J Respir Crit Care Med. 2019 Jun 15;199(12):1561-1563. doi: 10.1164/rccm.201809-1700RR.
2
Metformin: An Old Dog with a New Trick?
Cell Metab. 2018 Sep 4;28(3):334-336. doi: 10.1016/j.cmet.2018.08.018.
3
Metformin ameliorates bleomycin-induced pulmonary fibrosis in mice by suppressing IGF-1.
Am J Transl Res. 2020 Mar 15;12(3):940-949. eCollection 2020.
4
Metformin attenuates lung fibrosis development via NOX4 suppression.
Respir Res. 2016 Aug 30;17(1):107. doi: 10.1186/s12931-016-0420-x.
5
Thyroid function: Thyroid hormone therapy resolves pulmonary fibrosis in mice.
Nat Rev Endocrinol. 2018 Feb;14(2):64. doi: 10.1038/nrendo.2017.172. Epub 2017 Dec 22.
6
Metformin alleviates bleomycin-induced pulmonary fibrosis in rats: Pharmacological effects and molecular mechanisms.
Biomed Pharmacother. 2018 Jan;97:1544-1553. doi: 10.1016/j.biopha.2017.11.101. Epub 2017 Nov 22.
7
Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis.
Pulm Pharmacol Ther. 2019 Apr;55:75-83. doi: 10.1016/j.pupt.2019.02.005. Epub 2019 Feb 15.
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Metformin in Idiopathic Pulmonary Fibrosis "Seeking the Holy-Grail through Drug-Repositioning".
Respiration. 2018;96(4):305-307. doi: 10.1159/000490917. Epub 2018 Jul 13.
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The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis.
Exp Lung Res. 2015 Mar;41(2):57-73. doi: 10.3109/01902148.2014.979516. Epub 2014 Dec 16.

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Thyroid Hormone Pathways in Respiratory Diseases: Mechanism and Therapeutic Potential.
J Inflamm Res. 2025 Aug 4;18:10519-10531. doi: 10.2147/JIR.S529790. eCollection 2025.
2
Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis.
J Transl Med. 2024 Jun 27;22(1):598. doi: 10.1186/s12967-024-05398-y.
3
Effectiveness and mechanism of metformin in animal models of pulmonary fibrosis: A preclinical systematic review and meta-analysis.
Front Pharmacol. 2022 Sep 6;13:948101. doi: 10.3389/fphar.2022.948101. eCollection 2022.
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Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review.
Respir Res. 2021 Jun 8;22(1):175. doi: 10.1186/s12931-021-01760-6.

本文引用的文献

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Metformin Does Not Affect Clinically Relevant Outcomes in Patients with Idiopathic Pulmonary Fibrosis.
Respiration. 2018;96(4):314-322. doi: 10.1159/000489668. Epub 2018 Jul 19.
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Metformin reverses established lung fibrosis in a bleomycin model.
Nat Med. 2018 Aug;24(8):1121-1127. doi: 10.1038/s41591-018-0087-6. Epub 2018 Jul 2.
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Cholesterol Modification of an Anticancer Drug for Efficient Incorporation into a Supramolecular Hydrogel System.
Macromol Rapid Commun. 2018 Sep;39(17):e1800007. doi: 10.1002/marc.201800007. Epub 2018 May 28.
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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Nat Med. 2018 Jan;24(1):39-49. doi: 10.1038/nm.4447. Epub 2017 Dec 4.
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Therapeutic targets in idiopathic pulmonary fibrosis.
Respir Med. 2017 Oct;131:49-57. doi: 10.1016/j.rmed.2017.07.062. Epub 2017 Aug 1.
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Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis.
Am J Respir Crit Care Med. 2017 Dec 15;196(12):1571-1581. doi: 10.1164/rccm.201612-2480OC.
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Clinical trial research in focus: why do so many clinical trials fail in IPF?
Lancet Respir Med. 2017 May;5(5):372-374. doi: 10.1016/S2213-2600(17)30122-4. Epub 2017 Apr 12.

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