Małujło-Balcerska Elżbieta, Gałecka Maria, Pietras Tadeusz
Department of Pneumology, Medical University of Łódź, Łódź, Poland.
Medical University of Łódź, Łódź, Poland.
J Inflamm Res. 2025 Aug 4;18:10519-10531. doi: 10.2147/JIR.S529790. eCollection 2025.
Thyroid hormones (THs) influence a wide range of processes, from gene expression to complex signaling pathways, in almost every tissue. Over the past few years, there has been renewed interest in the TH synthesis, metabolism, secretion, and action; and the therapeutic potential of TH-related pathways and factors; as well as the mechanisms involved, including endocrine-immune/inflammatory relation. We hypothesize that TH-related factors and processes (ie, iodothyronine deiodinase, thyroid hormone transporters, etc) might influence the pathomechanism, disease course of respiratory pathology. TH-related molecules and processes may have the potential for use as indicators that may explain biological heterogeneity and/or be biomarkers of respiratory diseases. Furthermore, we postulate to explore whether the immune-inflammatory and/or other pathway components involved in lung diseases represent potential therapeutic agents. Exploration and validation of the distinctive utility of the abovementioned factors in respiratory disease should be planned and performed, paying attention to novel therapies and a panel of biomarkers, especially as the number of studies is limited and lacking, which makes it difficult to come to significant conclusions and find potential applications regarding respiratory diseases.
甲状腺激素（THs）几乎在每个组织中都影响着从基因表达至复杂信号通路等广泛的过程。在过去几年里，人们对TH的合成、代谢、分泌及作用，以及TH相关通路和因子的治疗潜力，还有所涉及的机制，包括内分泌-免疫/炎症关系，重新产生了兴趣。我们推测TH相关因子和过程（即碘甲状腺原氨酸脱碘酶、甲状腺激素转运体等）可能影响呼吸病理学的发病机制和病程。TH相关分子和过程可能有潜力用作解释生物学异质性和/或作为呼吸系统疾病生物标志物的指标。此外，我们假设探索参与肺部疾病的免疫炎症和/或其他通路成分是否代表潜在的治疗药物。应规划并开展对上述因素在呼吸系统疾病中独特效用的探索和验证，关注新型疗法和一系列生物标志物，尤其是鉴于相关研究数量有限且缺乏，这使得难以就呼吸系统疾病得出重要结论并找到潜在应用。
