Walters M T, Stevenson F K, Herbert A, Cawley M I, Smith J L
Ann Rheum Dis. 1986 Mar;45(3):210-9. doi: 10.1136/ard.45.3.210.
Three patients, two with typical primary Sjögren's syndrome (SS) and the third with several features of SS, including abnormal sialography and reduced tear secretion, developed B cell non-Hodgkin's lymphoma (NHL) of parotid or lung, or both. Isoelectric focusing of concentrated urine specimens in agarose, followed by immunofixation, demonstrated the presence in each patient's urine of monoclonal free light chains of the same class as that shown on the tumour cells. In one patient the level of urinary free light chains was monitored and found to correlate with disease activity. Similar techniques showed no monoclonal light chains in the urine from a further 26 cases of SS with no clinical evidence of lymphoma. The detection of monoclonal urinary free light chains may provide an early diagnostic clue to the development of lymphoma in patients with SS and be a means of tumour monitoring.
三名患者，其中两名患有典型的原发性干燥综合征（SS），第三名具有SS的若干特征，包括唾液腺造影异常和泪液分泌减少，均发生了腮腺或肺部或两者的B细胞非霍奇金淋巴瘤（NHL）。将浓缩尿液标本在琼脂糖中进行等电聚焦，随后进行免疫固定，结果显示每位患者尿液中均存在与肿瘤细胞上显示的相同类别的单克隆游离轻链。对一名患者的尿游离轻链水平进行监测，发现其与疾病活动相关。类似技术显示，另外26例无淋巴瘤临床证据的SS患者尿液中未发现单克隆轻链。检测单克隆尿游离轻链可能为SS患者淋巴瘤的发生提供早期诊断线索，并成为肿瘤监测的一种手段。
