Low D E, Shoenut J P, Kennedy J K, Harding G K, Den Boer B, Micflikier A B
Arch Intern Med. 1986 Mar;146(3):569-71.
We prospectively assessed the infectious complications of esophageal injection sclerotherapy (EIS) in 38 patients who underwent 104 procedures. Blood cultures were taken prior to and five and ten minutes after injection of the sclerosing agent in all procedures in an attempt to determine the frequency of positive blood cultures. Surveillance cultures were obtained from each patient's pharynx and from the biopsy channel of the endoscope to identify potential sources of bacteremia. The rate of blood culture positivity before injection was not significantly different from that after injection (1.9% vs 4.3%). In only one procedure was the same organism isolated five and ten minutes after sclerotherapy. The isolate in both samples was a Corynebacterium species. Endoscope surveillance cultures were positive prior to 42 of 102 procedures, although none of those organisms subsequently were isolated in the blood cultures. Since the rate of positive blood cultures following EIS is no greater than that before the procedure, the use of prophylactic antibiotics is unnecessary.
我们前瞻性地评估了38例接受104次食管注射硬化疗法（EIS）患者的感染并发症。在所有操作中，于注射硬化剂前、注射后5分钟和10分钟采集血培养样本，以确定血培养阳性的频率。从每位患者的咽部和内镜活检通道获取监测培养样本，以识别菌血症的潜在来源。注射前血培养阳性率与注射后无显著差异（1.9%对4.3%）。仅在一次操作中，硬化疗法后5分钟和10分钟分离出相同的微生物。两个样本中的分离菌均为棒状杆菌属。102次操作中有42次在内镜监测培养中呈阳性，尽管这些微生物随后均未在血培养中分离出来。由于EIS后血培养阳性率不高于操作前，因此无需使用预防性抗生素。
