急性室性心律失常患者中R-和S-妥卡尼的药代动力学。
The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias.
作者信息
Thomson A H, Murdoch G, Pottage A, Kelman A W, Whiting B, Hillis W S
出版信息
Br J Clin Pharmacol. 1986 Feb;21(2):149-54. doi: 10.1111/j.1365-2125.1986.tb05169.x.
Abstract
The pharmacokinetics of R(-) and S(+)- tocainide were studied in twelve patients requiring intravenous tocainide. In all patients, a progressive increase in the S(+):R(-) ratio was observed during the infusion. Mean +/- s.d. ratios increased from 1.03 +/- 0.05 at 2 min to 1.76 +/- 0.35 at 48.5 h. Data from eight patients were fitted to a two-compartment model and there was a significant difference (Wilcoxon matched-pairs test P less than 0.01) in the clearance estimates for the two enantiomers. The median values were: S(+)-tocainide = 6.25 l h-1 and R(-)-tocainide = 9.31 l h-1. There was no differences in V1 or Vss.
摘要
对12名需要静脉注射妥卡尼的患者研究了R(-)和S(+) - 妥卡尼的药代动力学。在所有患者中，输注期间观察到S(+):R(-)比值逐渐增加。平均值±标准差比值从2分钟时的1.03±0.05增加到48.5小时时的1.76±0.35。8名患者的数据拟合为二室模型，两种对映体的清除率估计值存在显著差异（Wilcoxon配对检验P<0.01）。中位数为：S(+)-妥卡尼 = 6.25 l h-1，R(-)-妥卡尼 = 9.31 l h-1。V1或Vss无差异。
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