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由瓦里安 Halcyon MV 锥形束 CT 分次图像引导治疗床移动引起的剂量计算偏差。

Dose calculation deviations induced by fractional image-guided-couch-shifts for Varian Halcyon MV cone beam CT.

机构信息

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Varian Medical Systems, 8 Yuncheng Street, BDA Beijing 100176, China.

出版信息

Phys Med. 2019 Feb;58:66-71. doi: 10.1016/j.ejmp.2019.01.015. Epub 2019 Jan 30.

Abstract

PURPOSE

To assess the criticality of calculation deviations induced by fractional image-guided-couch-shifts for Halcyon MV cone beam CT (CBCT) dose, which is incorporated as part of total treatment dose.

METHODS

Eclipse-calculated imaging dose was first validated in 'Cheese Phantom' by measurement. Then, the actual imaging dose (D) for 18 historical patients of various sites were recalculated based on 513 MV CBCT-guided-couch-shift data, and compared with reference computations based on treatment isocentre (D). Patient- and plan-specific dose from treatment fields was integrated with D and D respectively for comparison.

RESULTS

The average absolute relative disagreements between the measured and calculated dose were less than 1.23%. The mean ± 1SD of gamma passing rates of the accumulated imaging dose and total dose were 80.71 ± 6.22% and 99.81 ± 0.32% respectively based on 3 mm/3%/local/10% threshold criteria. The accumulated errors of minimum imaging dose to PTV were no larger than -14.38 cGy, which were reduced to -0.82 cGy after the heterogeneous treatment dose was overlaid. The mean relative discrepancies of PTV minimum dose were -0.61 cGy (-0.71%) and -0.00 (0.00%), before and after incorporating the treatment dose respectively.

CONCLUSIONS

The Eclipse-calculated Halcyon MV CBCT dose was validated. Although the isocentre displacement-induced imaging dose calculation errors for Halcyon MV CBCT were partially cancelled out by couch shifts of various directions and distances, especially after the incorporation of heterogeneous treatment dose, it was still advisable to monitor the accumulated deviations and replan when unacceptable target under-dose or organ over-dose were observed.

摘要

目的

评估 Halcyon MV 锥形束 CT(CBCT)剂量中因分次图像引导的治疗床位移引起的计算偏差的关键性,该剂量被整合到总治疗剂量中。

方法

首先通过测量验证 Eclipse 计算的成像剂量。然后,根据 513 次 MV CBCT 引导的治疗床位移数据,重新计算 18 名不同部位的历史患者的实际成像剂量(D),并与基于治疗等中心(D)的参考计算值进行比较。将患者和计划特定的治疗场剂量分别与 D 和 D 进行积分以进行比较。

结果

测量和计算剂量之间的平均绝对相对差异小于 1.23%。基于 3mm/3%/局部/10%的阈值标准,累积成像剂量和总剂量的累积伽马通过率的平均值±1SD 分别为 80.71±6.22%和 99.81±0.32%。PTV 的最小成像剂量的累积误差不大于-14.38cGy,在叠加不均匀的治疗剂量后,降低至-0.82cGy。在纳入治疗剂量之前和之后,PTV 最小剂量的平均相对差异分别为-0.61cGy(-0.71%)和-0.00(0.00%)。

结论

验证了 Eclipse 计算的 Halcyon MV CBCT 剂量。尽管 Halcyon MV CBCT 由于各向异性的治疗床位移引起的成像剂量计算误差部分被各种方向和距离的治疗床位移抵消,但在纳入不均匀的治疗剂量后,仍然建议监测累积偏差,并在观察到目标剂量不足或器官剂量过大时重新计划。

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