College of Veterinary Medicine, Northwest A&F University, No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.
College of Chemistry & Pharmacy, Northwest A&F University, No. 22 Xinong Road, Yangling, 712100, Shaanxi, China.
Behav Brain Res. 2019 Jun 3;365:26-35. doi: 10.1016/j.bbr.2019.02.044. Epub 2019 Feb 27.
Chronic mild stress (CMS) model is most similar to the depression human suffered in daily life. Strong evidence proved the important role of hippocampal synaptic plasticity in the mechanism of depression. This study investigated the effect of CMS on synaptic plasticity in hippocampus. Our results showed that CMS impaired spatial memory and exploring ability, disturbed the release of neurotransmitters including 5-hydroxytryptamine (5-HT) and dopamine (DA), reduced the density of synaptic vesicle in inner molecular layer, increased the number of thin spines in inner and outer molecular layer, whereas did not affect the density of spine apparatus, the above mentioned were probably related to the reduction of astrocytes and activation of microglial cells.
慢性轻度应激（CMS）模型与人类日常生活中所遭受的抑郁症最为相似。大量证据证明了海马突触可塑性在抑郁症发病机制中的重要作用。本研究探讨了 CMS 对海马突触可塑性的影响。我们的结果表明，CMS 损害了空间记忆和探索能力，扰乱了包括 5-羟色胺（5-HT）和多巴胺（DA）在内的神经递质的释放，减少了内分子层中突触小泡的密度，增加了内外分子层中薄棘突的数量，而不影响棘突小体的密度，上述变化可能与星形胶质细胞的减少和小胶质细胞的激活有关。
