Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada.
Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada; University Health Network, Toronto, Ontario, Canada.
Can J Cardiol. 2019 Mar;35(3):341-351. doi: 10.1016/j.cjca.2019.01.004.
Geographic factors may influence cardiovascular disease outcomes in Canada. Circulatory diseases are a major reason for higher population mortality rates in Northern Ontario, but it is unknown if hospitalized patients with cardiovascular disease experience differential outcomes compared with those in the South.
We examined 30-day and 1-year mortality and readmissions for patients hospitalized with acute myocardial infarction (AMI), heart failure (HF), atrial fibrillation (AF), or stroke in Northern compared with Southern Ontario, using the Canadian Institute for Health Information Discharge Abstract Database (2005-2016). Northern patients were defined as those residing and hospitalized in the Northwest or Northeast Local Health Integration Network regions. We used multiple Cox proportional hazards regression analysis for time-to-first event and Prentice-Williams-Peterson method to evaluate repeat and multiply admitted patients.
A total of 47,745 Northern and 465,353 Southern patients hospitalized with AMI (n = 182,158), HF (n = 130,770), AF (n = 72,326), or stroke (n = 127,844) were studied. Rates of first readmission were higher among Northern patients for AMI (adjusted hazard ratio [HR], 1.32), HF (HR, 1.16), AF (HR, 1.21), and stroke (HR, 1.27) compared with Southern patients (all P < 0.001). Repeat readmission rates among Northern patients for AMI (HR, 1.23), HF (HR, 1.13), AF (HR, 1.18), and stroke (HR, 1.22) were also increased (all P < 0.001 vs Southern). Thirty-day mortality did not differ significantly between Northern and Southern patients.
Readmissions were increased in those residing and hospitalized in the North. To reduce readmissions in the North, the quality of postacute transitional care should be examined further.
地理因素可能会影响加拿大的心血管疾病结果。在安大略省北部,循环系统疾病是导致人口死亡率较高的主要原因,但尚不清楚患有心血管疾病的住院患者是否与南部患者的预后结果存在差异。
我们利用加拿大健康信息研究所出院摘要数据库(2005 年至 2016 年),对安大略省北部和南部因急性心肌梗死(AMI)、心力衰竭(HF)、心房颤动(AF)或中风住院的患者进行了 30 天和 1 年死亡率及再入院率的比较。北部患者定义为居住和住院于西北地区或东北地区地方卫生整合网络地区的患者。我们使用多变量 Cox 比例风险回归分析进行首次事件时间分析,并用 Prentice-Williams-Peterson 方法评估重复和多次入院的患者。
共纳入 47745 名北部和 465353 名南部因 AMI(n=182158)、HF(n=130770)、AF(n=72326)或中风(n=127844)住院的患者。与南部患者相比,北部患者的首次再入院率更高,包括 AMI(校正后的危险比[HR],1.32)、HF(HR,1.16)、AF(HR,1.21)和中风(HR,1.27)(均 P<0.001)。北部患者的重复再入院率也有所增加,包括 AMI(HR,1.23)、HF(HR,1.13)、AF(HR,1.18)和中风(HR,1.22)(均 P<0.001 比南部)。30 天死亡率在北部和南部患者之间无显著差异。
居住和住院于北部的患者再入院率增加。为了减少北部的再入院率,应进一步检查急性后过渡期的医疗质量。