Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil; Interdisciplinary Center for Biochemical Investigation (CIIB), University of Mogi das Cruzes (UMC), Mogi das Cruzes, SP, Brazil.
Center for Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo André, SP, Brazil.
Biochem Pharmacol. 2019 May;163:357-361. doi: 10.1016/j.bcp.2019.02.032. Epub 2019 Feb 28.
Calcium is a well-studied ion that acts as a cofactor in several reactions and as intracellular second messenger. It plays crucial roles in living cells by regulating several processes from cell division to death. The disruption of Ca homeostasis is related to cell and tissue damage and it is involved in several pathological conditions and diseases, including cancer. Tumor cells exhibit several molecular features in relation to normal cells in order to acquire proliferative and survival advantages, and Ca signaling is directly or indirectly involved in these pathways. Thus, changes in the expression of Ca channels and pumps are frequently described in some cancers, including transient receptor potential (TRP) family channels, store- and voltage-gated Ca channels, store release channels, and Ca ATPases. Although the sodium/calcium exchanger (Na/Ca exchanger; NCX) and the therapeutic potential of its inhibitors have been extensively studied in heart diseases, there are few studies about the molecular and functional aspects of NCX in cancer. Here, the current knowledge about NCX in cancer will be reviewed and possible strategies to target NCX for cancer therapy will be discussed.
钙是一种研究充分的离子，它作为几种反应的辅助因子，并作为细胞内的第二信使。它通过调节从细胞分裂到死亡的几个过程，在活细胞中发挥着至关重要的作用。钙稳态的破坏与细胞和组织损伤有关，它涉及到几种病理状况和疾病，包括癌症。肿瘤细胞表现出与正常细胞相关的几种分子特征，以获得增殖和生存优势，而钙信号直接或间接地参与这些途径。因此，一些癌症中钙通道和泵的表达变化经常被描述，包括瞬时受体电位（TRP）家族通道、储存和电压门控钙通道、储存释放通道和 Ca ATP 酶。尽管钠/钙交换器（Na/Ca 交换器；NCX）及其抑制剂的治疗潜力在心脏病中得到了广泛研究，但关于 NCX 在癌症中的分子和功能方面的研究很少。本文将综述 NCX 在癌症中的研究现状，并探讨针对 NCX 进行癌症治疗的可能策略。
