Wiebe R H, Handwerger S, Soules M
Fertil Steril. 1986 Apr;45(4):483-8. doi: 10.1016/s0015-0282(16)49273-3.
Episodic luteinizing hormone (LH) secretion was studied in 16 hyperprolactinemic women (microprolactinoma, 12; idiopathic, 4) with amenorrhea of 1.4 to 7 years' duration. Blood samples obtained through an indwelling venous catheter at 20-minute intervals over 5 hours were assayed for LH, follicle-stimulating hormone (FSH), prolactin (PRL), and estrogen (E) (selected samples). LH pulse patterns were divided arbitrarily into high-amplitude release (LH pulse greater than 10 mIU/ml) (n = 7), low-amplitude release (LH pulse less than 10 mIU/ml (n = 6), and no release (n = 3). Mean pulse frequencies in women with high-amplitude and low-amplitude release were 2.4 +/- 0.3 (mean +/- standard error) and 1.3 +/- 0.2 pulses/5 hours and differed significantly (P greater than 0.02), whereas mean percentages of secretory increment were 155% and 62%, respectively. Mean LH concentrations in the high-amplitude (18.0 +/- 0.8 mIU/ml), low-amplitude (13.2 +/- 0.6 mIU/ml), and no-pulse groups (7.5 +/- 0.2 mIU/ml) differed significantly (P greater than 0.02). Despite the different pulse patterns, mean serum FSH, PRL, and total E concentrations were similar. The lack of episodic LH release and/or low infrequent LH release could account for the absence of cyclic hypothalamic pituitary ovarian function, although other mechanism(s) may be operative in women with augmented LH secretory pulses.
对16名高催乳素血症女性（12例微泌乳素瘤，4例特发性）进行了研究，这些女性闭经时间为1.4至7年。通过留置静脉导管，每20分钟采集一次血样，共采集5小时，检测其中的促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）和雌激素（E）（部分样本）。LH脉冲模式被任意分为高幅度释放（LH脉冲大于10 mIU/ml）（n = 7）、低幅度释放（LH脉冲小于10 mIU/ml）（n = 6）和无释放（n = 3）。高幅度释放和低幅度释放女性的平均脉冲频率分别为2.4±0.3（平均值±标准误）和1.3±0.2次脉冲/5小时，差异有统计学意义（P>0.02），而分泌增加的平均百分比分别为155%和62%。高幅度组（18.0±0.8 mIU/ml）、低幅度组（13.2±0.6 mIU/ml）和无脉冲组（7.5±0.2 mIU/ml）的平均LH浓度差异有统计学意义（P>0.02）。尽管脉冲模式不同，但平均血清FSH、PRL和总E浓度相似。LH缺乏间歇性释放和/或LH释放频率低可能是下丘脑-垂体-卵巢功能无周期性的原因，尽管其他机制可能在LH分泌脉冲增加的女性中起作用。
