Li Dan, Cong Zhukai, Lyu Xiangpeng, Wu Changyi, Tao Yifan, Zhu Xi
Department of Intensive Care Unit, Peking University Third Hospital, Beijing 100191, China.
Department of Intensive Care Unit, Civil Aviation General Hospital, Beijing 100123, China.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Feb;31(2):244-247. doi: 10.3760/cma.j.issn.2095-4352.2019.02.026.
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are common critical syndromes. The causes of the syndrome are complex and diverse. The main pathological features are the diffuse inflammatory and protein-rich pulmonary edema caused by destruction of the blood-air barrier. Reactive oxygen species (ROS) mediate oxidative damage by oxidizing bio-macromolecules, including lipids, proteins and nucleic acid. Among many systems producing ROS, nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase-mediated ROS is the main source, and its functional subunit is the transmembrane subunit NOX family. The distribution of NOX family proteins in lung tissue is cell type dependent. NOX-derived ROS is involved in the defense function of lung tissue and related to the occurrence and development of ALI/ARDS. This review mainly describes the cell distribution, activation factors, and its relationship with the occurrence and development of ALI of the NOX family.
急性肺损伤（ALI）及其严重形式急性呼吸窘迫综合征（ARDS）是常见的危重症综合征。该综合征的病因复杂多样。主要病理特征是血-气屏障破坏导致的弥漫性炎症和富含蛋白质的肺水肿。活性氧（ROS）通过氧化生物大分子（包括脂质、蛋白质和核酸）介导氧化损伤。在众多产生ROS的系统中，烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶介导的ROS是主要来源，其功能亚基是跨膜亚基NOX家族。NOX家族蛋白在肺组织中的分布依赖于细胞类型。NOX衍生的ROS参与肺组织的防御功能，并与ALI/ARDS的发生发展相关。本文综述主要描述了NOX家族的细胞分布、激活因子及其与ALI发生发展的关系。
