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P435 与含有 DOPE 的脂质体偶联的 HER2/neu 衍生肽作为乳腺癌的有效预防性疫苗制剂。

P435 HER2/neu-derived peptide conjugated to liposomes containing DOPE as an effective prophylactic vaccine formulation for breast cancer.

机构信息

a Nanotechnology Research Center, Pharmaceutical Technology Institute , Mashhad University of Medical Sciences , Mashhad , Iran.

c Department of Pharmaceutical Nanotechnology , School of Pharmacy, Mashhad University of Medical Science , Mashhad , Iran.

出版信息

Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):665-673. doi: 10.1080/21691401.2019.1576702.

DOI:10.1080/21691401.2019.1576702
PMID:30829072
Abstract

The present study was aimed to develop an effective nanoliposomal vaccine delivery system with P435 HER2/neu-derived peptide conjugated to Maleimide-PEG2000-DSPE. The nanoliposome formulation composed of DSPC/DSPG/Chol/DOPE and monophosphoryl lipid A was used as an adjuvant. Liposomal formulations were prepared and their physical properties were characterized. Anti-tumoral efficacy of formulations was evaluated by immunization of tumor-bearing BALB/c mice and the generated immune response was studied by using ELISpot and flow cytometry analysis. The results of the study demonstrated Lip + DOPE + P535 formulation caused the lowest tumor size and the longest survival time in TUBO mice model and could make it a promising candidate in developing effective vaccines against HER2-positive breast cancers.

摘要

本研究旨在开发一种有效的纳米脂质体疫苗传递系统，该系统将 P435 HER2/neu 衍生肽与马来酰亚胺-PEG2000-DSPE 连接。该纳米脂质体配方由 DSPC/DSPG/Chol/DOPE 和单磷酰脂质 A 组成，用作佐剂。制备了脂质体配方并对其物理性质进行了表征。通过对荷瘤 BALB/c 小鼠进行免疫接种来评估制剂的抗肿瘤功效，并通过 ELISpot 和流式细胞术分析研究了所产生的免疫反应。研究结果表明，Lip + DOPE + P535 制剂在 TUBO 小鼠模型中引起的肿瘤体积最小，存活时间最长，有望成为开发针对 HER2 阳性乳腺癌的有效疫苗的候选药物。

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