State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Clin Hemorheol Microcirc. 2019;72(2):169-178. doi: 10.3233/CH-180458.
To explore the normal morphological features of the retinal periarteral capillary free zone (paCFZ) and the changes associated with severe non-proliferative diabetic retinopathy (NPDR) by optical coherence tomography angiography (OCTA).
A total of 148 normal subjects and 115 patients with severe NPDR were enrolled. Spectral-domain OCTA was used to acquire the image with a Cirrus prototype. Diameter and area of each paCFZ quadrant and adjacent large artery diameter was estimated.
In healthy subjects, the maximum width of paCFZ in the temporal quadrant (169.38 ± 19.26 μm) was smaller than the other three quadrants (all P <0.001). The ratio of maximum paCFZ width to artery caliber was much larger in the nasal quadrants than the rest quadrants (Ps <0.05). In patients with severe NPDR, both maximum width and area of paCFZ were significant larger, and the retinal artery inner diameters significant smaller in each quadrant compared to normal subjects (Ps <0.05). The ratio of paCFZ maximum width to artery caliber maximum width was significant greater, and the ratio of paCFZ area to artery caliber was significantly higher in all quadrants compared to normal eyes (Ps <0.05).
OCTA provides noninvasive and quantitative measurement of paCFZ dimensions. The maximum width and area of paCFZ quadrants and the ratios of these parameters to adjacent inner artery width and area are elevated in severe NPDR, suggesting that changes in paCFZ dimension can be used as clinical indices for diseases associated with changes in retinal microcirculation and oxygen pressure.PRÉCIS:Optical coherence tomography angiography revealed differences in retinal periarteral capillary free zone (paCFZ) morphometry between health retina and severe non-proliferative diabetic retinopathy. Morphometric indices of paCFZ may be useful for monitoring disease occurrence and progression.
通过光相干断层扫描血管造影术（OCTA）探索视网膜周动脉毛细血管无血管区（paCFZ）的正常形态特征以及与严重非增生性糖尿病视网膜病变（NPDR）相关的变化。
共纳入 148 名正常受试者和 115 名严重 NPDR 患者。使用 Cirrus 原型光谱域 OCTA 采集图像。估计每个 paCFZ 象限和相邻大动脉直径的直径和面积。
在健康受试者中，颞象限 paCFZ 的最大宽度（169.38±19.26μm）小于其他三个象限（均 P<0.001）。鼻象限最大 paCFZ 宽度与动脉口径的比值明显大于其他象限（均 Ps<0.05）。在严重 NPDR 患者中，与正常受试者相比，每个象限的 paCFZ 最大宽度和面积均显著增大，视网膜内动脉直径显著减小（均 Ps<0.05）。paCFZ 最大宽度与动脉口径最大宽度的比值明显增大，所有象限的 paCFZ 面积与动脉口径的比值明显升高（均 Ps<0.05）。
OCTA 提供了 paCFZ 尺寸的非侵入性和定量测量。严重 NPDR 时 paCFZ 象限的最大宽度和面积以及这些参数与相邻内动脉宽度和面积的比值升高，表明 paCFZ 尺寸的变化可作为与视网膜微循环和氧压变化相关疾病的临床指标。
