Sugiyama H, Maeda T, Akira S, Kishimoto S
J Immunol. 1986 Apr 15;136(8):3092-7.
An Abelson virus-transformed murine pre-B cell line class-switched from mu to gamma 3 or gamma 2b at the pre-B stage during culture. A class-switch was mediated by the deletion mechanism of the intervening CH genes on the active chromosome. This study showed for the first time that class-switching at the pre-B cell stage was not always confined to gamma 2b production.
一种阿贝尔森病毒转化的小鼠前B细胞系在培养过程中的前B阶段从μ类转换为γ3或γ2b类。类别转换是由活性染色体上间隔CH基因的缺失机制介导的。这项研究首次表明，前B细胞阶段的类别转换并不总是局限于γ2b的产生。
