药物引起的超敏反应机制。
Mechanisms of hypersensitivity reactions induced by drugs.
作者信息
Franceschini Fabrizio, Bottau Paolo, Caimmi Silvia, Cardinale Fabio, Crisafulli Giuseppe, Liotti Lucia, Saretta Francesca, Bernardini Roberto, Mori Francesca, Caffarelli Carlo
机构信息
UOC Pediatria, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", Ancona, Italy.
出版信息
Acta Biomed. 2019 Jan 28;90(3-S):44-51. doi: 10.23750/abm.v90i3-S.8160.
Abstract
Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.
摘要
药物不良反应包括药物过敏反应（DHRs），其可由免疫介导或非免疫介导。在日常临床实践中，大量未经证实和/或自我报告的DHRs是一个常见问题，对未来的处方选择和患者健康有相当大的影响。通过采用结构化诊断方法来确认或排除可疑药物，区分过敏反应和非过敏反应很重要，这不仅可以避免危及生命的反应，还可以减少DHRs的频繁过度诊断。
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