Bogolyubova A V, Abrosimov A Yu, Selivanova L S, Belousov P V
V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia.
National Medical Research Center for Endocrinology, Ministry of Health of Russia, Moscow, Russia; National Research Technological University 'Moscow Institute of Steel and Alloys', Moscow, Russia.
Arkh Patol. 2019;81(1):46-51. doi: 10.17116/patol20198101146.
Papillary carcinoma is the most commonly diagnosed form of well-differentiated thyroid cancer that is generally characterized by a favorable prognosis. However, a number of relatively rare variants of this tumor, such as papillary carcinoma of high cells, papillary carcinoma of columnar cells, a diffuse sclerosing variant and recently described cancer of shoe nail cell type, are characterized by a less favorable clinical course, a high frequency of distant metastasis, and relatively low overall and relapse-free survival rates. In this connection, it is important to recognize these options at the stage of a primary morphological study. This review of the literature considers the morphological, clinical and molecular genetic features of the above variants of papillary thyroid carcinoma.
乳头状癌是分化良好的甲状腺癌最常见的诊断形式，通常预后良好。然而，这种肿瘤的一些相对罕见的变体，如高细胞型乳头状癌、柱状细胞型乳头状癌、弥漫性硬化变体以及最近描述的鞋钉细胞型癌，其临床病程较差，远处转移频率高，总体生存率和无复发生存率相对较低。因此，在原发性形态学研究阶段识别这些变体很重要。本文献综述探讨了上述甲状腺乳头状癌变体的形态学、临床和分子遗传学特征。
