Yokouchi-Konishi Tae, Yoshimatsu Jun, Sawada Masami, Shionoiri Tadasu, Nakanishi Atsushi, Horiuchi Chinami, Tsuritani Mitsuhiro, Iwanaga Naoko, Kamiya Chizuko A, Neki Reiko, Miyake Akira, Kurosaki Kenichi, Shiraishi Isao
Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Pediatr Cardiol. 2019 Apr;40(4):865-870. doi: 10.1007/s00246-019-02083-6. Epub 2019 Mar 4.
The frequency of newborns with congenital heart disease (CHD) is approximately 1% in the general population; however, the recurrence rate of CHD in mothers with CHD differs in ethnicity and reports. We therefore aimed to determine the prevalence of CHD among neonates born to mothers with CHD in our institute in Japan. We reviewed the medical charts of 803 neonates delivered by 529 women with CHD at the National Cerebral and Cardiovascular Center from 1982 to 2016. They included isolated ventricular septal defect (VSD,31.4%), isolated atrial septal defect (ASD, 23.3%), tetralogy of Fallot (TOF,10.6%). We defined CHD in neonates as being diagnosed within 1 month of birth. We estimated that the average rate of the CHD recurrence was 3.1%. The recurrence ratios in each maternal CHD were 8.6%, 7.1%, 6.2%, 4.8%, 3.6%, and 1.5% for PS, CoA, TOF, atrioventricular septal defect, VSD, and ASD, respectively. The rate of CHD in offsprings whose mothers have CHD was 3 times greater than that of mothers with healthy hearts. Almost half of neonates with CHD had the same phenotype as their mother in our series. Especially, PS and CoA were closely related to the type of maternal CHD.
先天性心脏病（CHD）新生儿在普通人群中的发生率约为1%；然而，患有CHD的母亲中CHD的复发率在不同种族和报告中有所不同。因此，我们旨在确定日本我们研究所中患有CHD的母亲所生新生儿中CHD的患病率。我们回顾了1982年至2016年在国立脑神经和心血管中心由529名患有CHD的女性所分娩的803名新生儿的病历。其中包括单纯室间隔缺损（VSD，31.4%）、单纯房间隔缺损（ASD，23.3%）、法洛四联症（TOF，10.6%）。我们将新生儿中的CHD定义为在出生后1个月内被诊断出。我们估计CHD的平均复发率为3.1%。每种母亲CHD类型的复发率分别为：肺动脉狭窄（PS）8.6%、主动脉缩窄（CoA）7.1%、TOF 6.2%、房室间隔缺损4.8%、VSD 3.6%、ASD 1.5%。母亲患有CHD的后代中CHD的发生率是心脏健康母亲的3倍。在我们的系列研究中，几乎一半患有CHD的新生儿具有与其母亲相同的表型。特别是，PS和CoA与母亲CHD的类型密切相关。
