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Allele frequency dynamics in a pedigreed natural population.遗传谱系自然群体中的等位基因频率动态。
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2158-2164. doi: 10.1073/pnas.1813852116. Epub 2018 Dec 31.
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Contingency and determinism in evolution: Replaying life's tape.进化中的偶然性和决定性:重演生命的磁带。
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Extreme copy number variation at a tRNA ligase gene affecting phenology and fitness in yellow monkeyflowers.tRNA 连接酶基因的极端拷贝数变异影响黄蔓花的物候和适应性。
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Maladaptive phenotypic plasticity in cardiac muscle growth is suppressed in high-altitude deer mice.高原鼠兔心肌生长的适应不良表型可塑性受到抑制。
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Remodeling Ancestral Phenotypic Plasticity in Local Adaptation: A New Framework to Explore the Role of Genetic Compensation in the Evolution of Homeostasis.重塑局部适应中的祖先表型可塑性:探索遗传补偿在稳态进化中作用的新框架。
Integr Comp Biol. 2018 Dec 1;58(6):1098-1110. doi: 10.1093/icb/icy117.
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The Peril of Gene-Targeted Conservation.基因靶向保护的危险。
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Guidelines for planning genomic assessment and monitoring of locally adaptive variation to inform species conservation.规划基因组评估和监测局部适应性变异以指导物种保护的指南。
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8
Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity in the rock pigeon.调控等位基因和错义编码突变的渗入驱动岩鸽的羽毛图案多样性。
Elife. 2018 Jul 17;7:e34803. doi: 10.7554/eLife.34803.
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Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares.适应性基因渗入是雪兔多态季节性保护色的基础。
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Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose.血红蛋白适应高空飞行的斑头雁的分子基础。
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揭示自然种群中基因型、表型和适合度之间的联系。

UNVEILing connections between genotype, phenotype, and fitness in natural populations.

机构信息

Division of Biological Sciences, University of Montana, Missoula, Montana.

University of Nebraska, Lincoln, Nebraska.

出版信息

Mol Ecol. 2019 Apr;28(8):1866-1876. doi: 10.1111/mec.15067. Epub 2019 May 5.

DOI:10.1111/mec.15067
PMID:30830713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6525050/
Abstract

Understanding the links between genetic variation and fitness in natural populations is a central goal of evolutionary genetics. This monumental task spans the fields of classical and molecular genetics, population genetics, biochemistry, physiology, developmental biology, and ecology. Advances to our molecular and developmental toolkits are facilitating integrative approaches across these traditionally separate fields, providing a more complete picture of the genotype-phenotype map in natural and non-model systems. Here, we summarize research presented at the first annual symposium of the UNVEIL Network, an NSF-funded collaboration between the University of Montana and the University of Nebraska, Lincoln, which took place from the 1st to the 3rd of June, 2018. We discuss how this body of work advances basic evolutionary science, what it implies for our ability to predict evolutionary change, and how it might inform novel conservation strategies.

摘要

理解遗传变异与自然种群适应度之间的联系是进化遗传学的核心目标。这项艰巨的任务跨越了经典遗传学和分子遗传学、群体遗传学、生物化学、生理学、发育生物学和生态学等领域。我们的分子和发育工具包的进步正在促进这些传统上分离的领域的综合方法,为自然和非模式系统中的基因型-表型图谱提供更完整的图景。在这里,我们总结了于 2018 年 6 月 1 日至 3 日在 UNVEIL 网络(该网络由美国国家科学基金会资助,由蒙大拿大学和内布拉斯加大学林肯分校联合成立)的首届年度研讨会上展示的研究。我们讨论了这项工作如何推进基础进化科学,它对我们预测进化变化的能力意味着什么,以及它如何为新的保护策略提供信息。