Lovén L, Larsson L, Nordström H, Lennquist S
J Trauma. 1986 Apr;26(4):348-52. doi: 10.1097/00005373-198604000-00008.
Serum phosphate (S-P) and 2,3-diphosphoglycerate (2,3-DPG) were monitored for 10 days after severe burn trauma in 16 patients treated with total parenteral nutrition, including supplementation with 25-75 mmol phosphate daily. Phosphate metabolism was previously shown to be disturbed in patients with severe burns, and hypophosphatemia has been reported to disturb oxygen transport by reducing synthesis of 2,3-DPG in the red cells. In this study, S-P was decreased in the first post-trauma week because of a negative phosphate balance the first 4 post-trauma days, but 2,3-DPG remained at normal concentrations. These findings indicate that post-traumatic disturbance in red-cell phosphate metabolism may be prevented by administration of phosphate and that such supplementation is important in the metabolic management of severely injured patients.
对16例接受全胃肠外营养治疗（包括每日补充25 - 75 mmol磷酸盐）的严重烧伤患者，在严重烧伤创伤后监测血清磷酸盐（S-P）和2,3-二磷酸甘油酸（2,3-DPG）10天。先前已表明严重烧伤患者的磷酸盐代谢紊乱，并且有报道称低磷血症会通过减少红细胞中2,3-DPG的合成来干扰氧运输。在本研究中，创伤后第一周S-P降低，这是由于创伤后前4天磷酸盐呈负平衡，但2,3-DPG浓度保持正常。这些发现表明，通过给予磷酸盐可预防创伤后红细胞磷酸盐代谢紊乱，并且这种补充在严重受伤患者的代谢管理中很重要。
