Wood R J, Sitrin M D, Cusson G J, Rosenberg I H
JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):188-90. doi: 10.1177/0148607186010002188.
Hypercalciuria and negative calcium balance are potential complications of total parenteral nutrition (TPN). Dietary phosphorus has been observed to have an hypocalciuretic effect. The present study evaluates the effects of administration of increasing intravenous phosphorus (P) loads on urinary calcium excretion in TPN patients. Urinary calcium exceeded daily calcium intake by 50 mg/d when 700 mg/d P was administered, was equal to intake at 1000 mg/d P, and was 30 mg/d less than calcium intake when 1300 mg/d P was given. These findings suggest that TPN-induced hypercalciuria can be attenuated in the short-term by intravenous phosphate. Reevaluation of the phosphorus requirement in patients receiving long-term TPN should be considered.
高钙尿症和负钙平衡是全胃肠外营养（TPN）的潜在并发症。已观察到膳食磷具有减少尿钙排泄的作用。本研究评估了增加静脉磷（P）负荷对TPN患者尿钙排泄的影响。当给予700mg/d的磷时，尿钙超过每日钙摄入量50mg/d；给予1000mg/d的磷时，尿钙与摄入量相等；给予1300mg/d的磷时，尿钙比钙摄入量少30mg/d。这些发现表明，静脉输注磷酸盐可在短期内减轻TPN诱导的高钙尿症。应考虑对接受长期TPN的患者重新评估磷的需求量。
