Watanabe H, Taniguchi M
Jpn J Pharmacol. 1986 Jan;40(1):185-7. doi: 10.1254/jjp.40.185.
Subchronic treatment with methamphetamine (3 mg/kg, s.c., twice daily for 14 days) attenuated hypomotility produced by a low dose of apomorphine (0.1 mg/kg, s.c.) and enhanced hypermotility induced by a high dose of apomorphine (3 mg/kg, s.c.) in mice. The treatment did not affect apomorphine-induced decrease in striatal DOPA accumulation following gamma-butyrolactone plus m-hydroxybenzylhydrazine, an L-amino acid decarboxylase inhibitor, administration. These results suggest that drug sensitivity of presynaptic dopamine receptors in the striatum may not be altered after subchronic methamphetamine treatment.
用甲基苯丙胺进行亚慢性治疗（3毫克/千克，皮下注射，每日两次，共14天）可减轻低剂量阿扑吗啡（0.1毫克/千克，皮下注射）引起的小鼠运动迟缓，并增强高剂量阿扑吗啡（3毫克/千克，皮下注射）诱导的小鼠运动亢进。该治疗不影响在给予γ-丁内酯加L-氨基酸脱羧酶抑制剂间羟基苄基肼后阿扑吗啡诱导的纹状体多巴积累的减少。这些结果表明，亚慢性甲基苯丙胺治疗后纹状体中突触前多巴胺受体的药物敏感性可能未改变。
