Haematology Division, ICMR - Regional Medical Research Centre, N.E. Region, 786010, Dibrugarh, Assam, India.
Cancer Epidemiol. 2019 Apr;59:215-220. doi: 10.1016/j.canep.2019.02.010. Epub 2019 Mar 2.
This study aimed to investigate the distribution of multiple myeloma (MM) in India and provide a comprehensive narrative about its incidence, including differential patterns across age, sex and geography.
MM cases diagnosed during 2012-14 were obtained from 27 populations based cancer registries in India by consulting the latest National Cancer Registry Programme reports. Crude (CR) and age-specific (ASR) rates of MM incidence were determined. Age-adjusted rates (AARs) were estimated by standardizing the CR values using age-specific weights recommended for LMIC countries (including India) for men and women separately, along with the corresponding 95% confidence interval (95% CI) measures.
Altogether, 1916 MM cases (male/female: 1123/793) were documented (i.e. 1.19% of all cancers, 95% CI: 1.14-1.24%). Overall CR of MM in India was 1.27 (95% CI: 1.20-1.35)/ 100,000 in men and 0.95 (95% CI: 0.89-1.02)/ 100,000 in women, while the corresponding AARs were 1.13 (95% CI: 1.07-1.20) and 0.81 (95% CI: 0.75 - 0.88) per 100,000 respectively. The ASR values increased steadily with age. Most cases belonged to the 60-69 yrs bracket. However, regional and sex-specific differences in MM profile were observed. MM incidence was highest in the Southern and Northern zones, and least in the Northeast. The Northern and Central zones had higher proportion of MM in the 50-59 yrs age group, whereas Eastern zone had higher proportion of cases aged 70 yrs and above.
Incidence of MM in India is presented. Marked variations in MM incidence were noted with respect to age, sex and geography.
本研究旨在调查印度多发性骨髓瘤（MM）的分布情况，并提供其发病情况的全面叙述，包括年龄、性别和地理位置方面的差异模式。
通过查阅最新的国家癌症登记计划报告，从印度的 27 个人口癌症登记处获取了 2012-14 年期间诊断的 MM 病例。确定了 MM 发病的粗发病率（CR）和年龄别发病率（ASR）。通过使用为印度等中等收入国家（LMIC）推荐的男女分别的年龄特异性权重对 CR 值进行标准化，估计了年龄调整发病率（AAR），并附有相应的 95%置信区间（95%CI）测量值。
共记录了 1916 例 MM 病例（男/女：1123/793）（即所有癌症的 1.19%，95%CI：1.14-1.24%）。印度 MM 的总体 CR 为男性 1.27（95%CI：1.20-1.35）/100000，女性 0.95（95%CI：0.89-1.02）/100000，相应的 AAR 分别为 1.13（95%CI：1.07-1.20）和 0.81（95%CI：0.75-0.88）/100000。ASR 值随年龄稳步上升。大多数病例属于 60-69 岁年龄段。然而，观察到 MM 分布在区域和性别方面存在差异。南部和北部地区的 MM 发病率最高，东北地区最低。北部和中部地区 50-59 岁年龄组的 MM 比例较高，而东部地区 70 岁及以上年龄组的病例比例较高。
报告了印度 MM 的发病率。在年龄、性别和地理位置方面，MM 的发病率存在明显差异。
