a The First Affiliated Hospital of Medical College of Xi'an Jiaotong University , Xi'an , China.
b The Xinjiang Uygur Autonomous Region Maternal and Child Health Care Hospital , Urumqi , China.
Artif Cells Nanomed Biotechnol. 2018;46(sup3):S281-S286. doi: 10.1080/21691401.2018.1491480.
It was previously reported that the ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) can predict the clinical onset of preeclampsia. This study seeks to validate the association between ratios of sFlt-1/PlGF with preeclampsia and to identify the contribution of ethnicity across diverse populations of the Xinjiang Uygur Autonomous Region.
Pregnant women were classified into those with preeclampsia (n = 136) and healthy controls (n = 350). Serum levels of sFlt-1 and PlGF were quantified using a Roche serum instrument in both patients and controls.
Compared to healthy controls, women with preeclampsia had significantly higher levels of sFlt-1 (7303.81 pg/ml vs. 2508.69 pg/ml, p < .001) and ratios of sFlt-1/PlGF (241.68 vs. 14.29, p < .001), whereas levels of PIGF were decreased (241.68 vs. 14.29, p < .001). These three values varied greatly across nationalities, and non-Han Chinese subjects (including Uygur, Kazak, Hui) were more likely to experience severe preeclampsia than Han Chinese subjects.
This is the first study to demonstrate that the ratio of sFlt-1/PlGF can both predict and serve as a diagnostic factor for preeclampsia in pregnant women from different populations within the Xinjiang region of China.
此前有报道称，可溶性 fms 样酪氨酸激酶-1（sFlt-1）与胎盘生长因子（PlGF）的比值可预测子痫前期的临床发病。本研究旨在验证 sFlt-1/PlGF 比值与子痫前期的相关性，并确定不同民族在新疆维吾尔自治区人群中的贡献。
将孕妇分为子痫前期组（n=136）和健康对照组（n=350）。采用罗氏血清仪器对患者和对照组的血清 sFlt-1 和 PlGF 水平进行定量检测。
与健康对照组相比，子痫前期患者的 sFlt-1 水平（7303.81 pg/ml 比 2508.69 pg/ml，p <.001）和 sFlt-1/PlGF 比值（241.68 比 14.29，p <.001）明显升高，而 PlGF 水平降低（241.68 比 14.29，p <.001）。这三个值在不同民族之间差异很大，非汉族（包括维吾尔族、哈萨克族、回族）患者比汉族患者更容易发生重度子痫前期。
这是首次研究表明，sFlt-1/PlGF 比值不仅可以预测子痫前期，还可以作为中国新疆地区不同人群孕妇子痫前期的诊断因素。
