Tang Ping, Xu Jing, Xie Bao-Jun, Wang Qi-Mei
a Obstetrics Department , The Second People's Hospital of Liaocheng City , Liaocheng, Shandong Province, P. R . China.
b Department of Clinical Laboratory , The Second People's Hospital of Liaocheng City , Liaocheng, Shandong Province, P. R . China.
Hypertens Pregnancy. 2017 Feb;36(1):48-52. doi: 10.1080/10641955.2016.1237642. Epub 2016 Nov 11.
Preeclampsia (PE) is a disorder of pregnancy marked by hypertension and proteinuria with no known treatment aside from pregnancy termination. The pathogenesis of PE is poorly understood, but is thought to originate in the placenta. We assessed the value of measuring serum and urinary soluble deformylase-like tyrosine kinase receptor 1 (sFlt-1), a known target of placental factors, and placental growth factor (PLGF), a key placental signaling molecule, in the diagnosis of PE.
Eighty patients with PE were classified as either exhibiting mild (44 cases) or severe (36 cases) symptoms of PE. Forty normal pregnant women were selected as controls. Serum and urinary PLGF and sFlt-1 levels, along with the ratio of sFlt-1 to PLGF, were compared across groups.
Serum and urinary sFlt-1 and sFlt-1/PLGF ratios in severe PE patients were significantly higher than those in the mild PE group, and measurements from mild PE patients were significantly higher than controls (all P values <0.01). The serum and urinary PLGF levels in severe PE patients were significantly lower than mild PE patients, and mild PE patients had significantly lower PLGF levels than controls (all P values <0.01). As expected, serum sFlt-1 and PLGF levels and ratios were highly correlated with urinary sFlt-1 and PLGF levels and ratios.
The severity of PE was closely correlated with these measurements, suggesting that they may be useful tools in the diagnosis and evaluation of PE.
子痫前期（PE）是一种妊娠疾病，其特征为高血压和蛋白尿，除终止妊娠外尚无已知治疗方法。PE的发病机制尚不清楚，但认为起源于胎盘。我们评估了测量血清和尿液中可溶性去甲酰化酶样酪氨酸激酶受体1（sFlt-1，一种已知的胎盘因子靶点）和胎盘生长因子（PLGF，一种关键的胎盘信号分子）在PE诊断中的价值。
80例PE患者被分为轻度（444例）或重度（36例）PE症状组。选择40名正常孕妇作为对照组。比较各组血清和尿液中PLGF和sFlt-1水平以及sFlt-1与PLGF的比值。
重度PE患者的血清和尿液sFlt-1及sFlt-1/PLGF比值显著高于轻度PE组，轻度PE患者的测量值显著高于对照组（所有P值<0.01）。重度PE患者的血清和尿液PLGF水平显著低于轻度PE患者，轻度PE患者的PLGF水平显著低于对照组（所有P值<0.01）。正如预期的那样，血清sFlt-1和PLGF水平及比值与尿液sFlt-1和PLGF水平及比值高度相关。
PE的严重程度与这些测量值密切相关，表明它们可能是PE诊断和评估的有用工具。
