儿科研究的全球化：拉丁美洲的药理学 RCT 研究。
Globalization of pediatric research: pharmacological RCTs in Latin America.
机构信息
Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di RicercheFarmacologiche "Mario Negri", Via Giuseppe la Masa 19, 20156, Milan, Italy.
Department of Pediatrics, Hospital S. Gerardo/Fondazione MBBM, University of Milano-Bicocca, Monza, Italy.
出版信息
Ital J Pediatr. 2019 Mar 4;45(1):29. doi: 10.1186/s13052-019-0622-1.
Globalization caused a shift in trial locations towards low-middle income countries, raising ethical concerns. These include the risk that conditions primarily affecting children in these countries will be neglected in favor of those affecting developed countries. We analyzed 253 published and 69 ongoing pharmacological RCTs performed in Latin America between 2000 and 2015 involving exclusively children. While over 50% of the previously highly investigated diseases were no longer priorities, other diseases acquired greater attention in recent years. Brazil and Mexico resulted as the most active countries. A large gap remains between the real needs of children in these countries and scientific research.
全球化导致试验地点向中低收入国家转移，引发了伦理问题。其中包括这些国家主要影响儿童的疾病可能被忽视，转而关注发达国家的疾病。我们分析了 2000 年至 2015 年期间在拉丁美洲进行的 253 项已发表和 69 项正在进行的药理学 RCT，这些试验仅涉及儿童。虽然以前高度研究的疾病中有超过 50%不再是优先事项，但近年来其他疾病受到了更多关注。巴西和墨西哥是最活跃的国家。这些国家的儿童的实际需求与科学研究之间仍然存在很大差距。
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